57667-07-9

Upstream product

• 98-01-1 furfural 
• 57268-39-0 5‐(4‐acetylphenyl)‐2‐furaldehyde 
• 617-90-3 2-furancarbonitrile 
• 99-90-1 para-bromoacetophenone 
• 99-92-3 p-aminobenzophenone 
• 57667-06-8 5-(4-Acetyl-phenyl)-furan-2-carbaldehyde oxime 

Downstream Products

• 57667-28-4 5-(4-Acetyl-phenyl)-furan-2-carboxamidine; hydrochloride 
• 57667-08-0 methyl 5-<4'-(hydroxyethylphenyl)>-2-furimidate 

Relevant academic research and scientific papers

Fluorosolvatochromism of furanyl- and thiophenyl-substituted acetophenones

A series of para-substituted acetophenones bearing a furanyl or a thiophenyl moiety show a large Stokes-shift, which is a function of various solvent properties. Photophysical properties such as emission lifetime of the compounds have been determined using time-correlated-single photon counting to secure the intrinsic fluorescence behaviour. The solvent dependent position of the UV/Vis emission band max,em of the compounds has been measured in 26 various solvents. The influence of the solvent on max,em is of very complex nature and mathematically analysed by multiple square linear solvation energy (LSE)-correlation analysis using Catalán's four-solvent parameter set. Solvent acidity has a strong influence on the bathochromic shift of 2,5-disubstituted furan derivatives compared to the non-5-substituted furan and thiophene derivatives, which show a contrary behaviour. Therefore, the 5-cyanofuranyl-substituted acetophenone derivative is useful as a probe for measuring environmental properties by fluorescence spectroscopy.

5-Phenyl-2-furamidines: A new chemical class of potential antidepressants

A series of 5-phenyl-2-furamidines has been synthesized and evaluated for antidepressant activities. Substitution in the phenyl ring with a nitro (4) or an amino (12) group in the ortho-position resulted in an increase in antidepressant activity. Both 4 and 12 antagonized tetrabenazine-induced ptosis in rodents and inhibited norepinephrine (noradrenaline) uptake into crude synaptosomes of whole mouse brain at doses or concentrations comparable to those of the tricyclic antidepressants. However, these compounds did not possess the anticholinergic and antihistaminic activities common to tricyclic antidepressants. In addition, they lacked monoamine oxidase inhibitory activity. The 5-phenyl-2-furamidines represent a new chemical class of antidepressants and may be useful for depressive patients who cannot tolerate the compromising side effects of the tricyclic antidepressants and monoamine oxidase inhibitors.

5-PHENYL-2-FURAMIDOXIMES

A series of 5-phenyl-2-furamidoximes are useful as antidepressants.