5767-84-0

Usage

InChI:InChI=1/C23H16N2O5/c1-14-11-17(24-22(26)16-6-4-7-18(12-16)25(28)29)9-10-19(14)20-13-15-5-2-3-8-21(15)30-23(20)27/h2-13H,1H3,(H,24,26)

Upstream product

• 22610-63-5 octadecanoic acid 2,3-dihydroxypropyl ester 
• 6289-31-2 allyl stearate 
• 64-19-7 acetic acid 
• 1146530-68-8 octadecanoic acid benzyloxycarbonylmethyl ester 
• 57-11-4 stearic acid 
• 79-14-1 glycolic Acid 
• 112-76-5 Stearoyl chloride 

Downstream Products

• 111-61-5 stearic acid ethyl ester 
• 5060-55-9 Prednisolon-21-stearoylglycolat 
• 1146530-71-3 trclosan glycolic acid stearate 

Relevant academic research and scientific papers

EXTRAHEPATIC DELIVERY

One aspect of the present invention relates to a compound comprising an antisense strand which is complementary to a target gene; a sense strand which is complementary to said antisense strand; and one or more lipophilic monomers, containing one or more lipophilic moieties, conjugated to one or more positions on at least one strand, optionally via a linker or carrier. Another aspect of the invention relates to a method of gene silencing, comprising administering to a cell or a subject in need thereof a therapeutically effective amount of the lipophilic monomer-conjugated compound.

TRANSTHYRETIN (TTR) IRNA COMPOSITION AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED OCULAR DISEASES

The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR- associated ocular diseases.

ABSORBABLE BRANCHED POLYESTERS AND POLYURETHANES

The present invention relates to the discovery of a new class of hydrolysable isocyanates, hydrolysable branched polyols and branched absorbable polyesters and polyurethanes prepared therefrom. The resultant absorbable polymers are useful for drug delivery, stents, highly porous foam, reticulated foam, tissue engineering, tissue adhesives, adhesion prevention, bone wax formulations, medical device coatings, surface modifying agents and other implantable medical devices. In addition, these absorbable polymers can have a controlled hydrolytic degradation profile.

Functionalized biodegradable triclosan monomers and oligomers for controlled release

This invention relates to the discovery of functionalized triclosan monomers and oligomers that, when incorporated into a substrate of, or applied as part of a coating to, medical devices and/or consumer products may extend the duration of antimicrobial properties to the medical devices and/or consumer products.