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Usage

Uses

Used in Pharmaceutical Industry:
Hexahydro-3H-pyrrolo[1,2-c]imidazole-1,3-dione is used as a key intermediate in the synthesis of various pharmaceuticals for its potential to contribute to the development of new drugs with antitumor, antiviral, and antibacterial properties. Its unique structure allows for the creation of compounds that can target specific biological pathways, offering therapeutic benefits in treating a range of diseases.
Used in Agrochemical Industry:
In the agrochemical sector, Hexahydro-3H-pyrrolo[1,2-c]imidazole-1,3-dione is utilized as a component in the formulation of pesticides and other crop protection agents. Its biological activities, such as antibacterial properties, make it a valuable asset in developing effective solutions to combat plant diseases and pests, thereby enhancing crop yields and quality.
Used in Natural Product Synthesis:
Hexahydro-3H-pyrrolo[1,2-c]imidazole-1,3-dione is employed as a building block in the synthesis of natural products, leveraging its structural features to mimic or enhance the properties of naturally occurring compounds. This application is particularly relevant in the development of novel therapeutic agents that harness the power of nature while benefiting from the advancements in synthetic chemistry.
Used in Chemical Research:
As a subject of chemical research, Hexahydro-3H-pyrrolo[1,2-c]imidazole-1,3-dione is used to explore new synthetic pathways, understand its reactivity, and investigate its potential applications in material science and other fields. Hexahydro-3H-pyrrolo[1,2-c]imidazole-1,3-dione's unique structure and properties make it an intriguing candidate for fundamental studies aimed at uncovering new chemical reactions and mechanisms.

InChI:InChI=1/C6H8N2O2/c9-5-4-2-1-3-8(4)6(10)7-5/h4H,1-3H2,(H,7,9,10)

Upstream product

• 93188-01-3 2-(aminocarbonyl)-1-pyrrolidinecarboxylic acid, phenylmethyl ester 
• 108-91-8 cyclohexylamine 
• 81965-44-8 N-(2-chloroethyl)-N-nitrosocarbamoyl prolinamide 
• 367906-67-0 N-cyanoproline methyl ester 
• 609-36-9 rac-Pro-OH 
• 147-85-3 L-proline 
• 590-28-3 potassium cyanate 

Downstream Products

• 92763-94-5 3-<3-(m-methoxyphenyl)propyl>-1,3-diazabicyclo<3.3.0>octane-2,4-dione 
• 188914-67-2 2-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione 
• 326497-29-4 2-{3-[4-(2-butoxy-phenyl)-piperazin-1-yl]-propyl}-tetrahydro-pyrrolo[1,2-c]imidazole-1,3-dione 
• 336818-18-9 C₁₃H₁₂Cl₂N₂O₂ 
• 1000848-82-7 (±)-2-tosylhexahydro-3H-pyrrolo[1,2-c]imidazole-3-one 

Relevant academic research and scientific papers

3-(Triflyloxy)benzynes Enable the Regiocontrolled Cycloaddition of Cyclic Ureas to Synthesize 1,4-Benzodiazepine Derivatives

A versatile synthesis of 1,4-benzodiazepine derivatives through the reaction of various 3-(trifluoromethanesulfonyloxy)benzynes with N -(p -toluenesulfonyl)imidazolidin-2-ones is reported. This reaction system provides a 1,4-benzodiazepine bearing a trifluoromethanesulfonyloxy group as a single regioisomer among the four possible regioisomers.

Highly efficient dialkylphosphate-mediated syntheses of hydantoins and a bicyclohydantoin under solvent-free conditions

Diversely substituted hydantoins have been synthesized by new strategy from cyanamide based precursor, that is, methyl N-cyano-N-alkyl/arylaminoacetate. Dialkylphosphates were employed as the mild reagent to hydrolyze and cyclize the substrate in one step to give quantitative yields of the desired products. Syntheses of multivalent hydantoins viz bis-hydantoin, bicyclohydantoin have potentially widened the scope and applicability of the present method. Solvent-free conditions and very easy work-up procedure make the reaction convenient and eco-friendly. Single crystal structures of some of the representative compounds are also reported.

Decomposition of N-(2-chloroethyl)-N-nitrosocarbamoyl amino acid amides

The chemical decomposition of N-(2-chloroethyl)-N-nitrosocarbamoyl (Q(NO)) prolinamide and valinamide were studied under physiological conditions. The volatile products were identified with GC. Q(NO)-Pro-NH2 gave twice the amount of ethylene glycol and only one-fifth of the 2-chloroethanol produced by Q(NO)-Val-NH2 or BCNU, pointing to different pathways of their decomposition. The carbamoylating activity was also investigated in the presence of cyclohexylamine, and it was found to lead mainly to intramolecular carbamoylation with the formation of hydantoin derivatives.

Formation of By-products during Sodium-Liquid Ammonia Reduction in Peptide Chemistry

Reduction of protected model peptides by the usual excess of sodium in liquid ammonia leads to undesired by-products; the generally accepted blue colour for the end point is unnecessary for complete reduction.