5770-05-8 Usage
Uses
Used in Organic Synthesis:
METHANOL-18O is used as a chemical reagent for various organic synthesis applications. The presence of the 18O isotope allows for the study of reaction mechanisms and the investigation of kinetic isotope effects at low temperatures.
Used in Research and Development:
METHANOL-18O is used as a research tool in the field of chemistry, particularly for understanding the impact of isotopic substitution on reaction rates and mechanisms. This helps researchers gain insights into the fundamental principles governing chemical reactions and can lead to the development of more efficient synthetic pathways.
Used in Environmental Studies:
METHANOL-18O can be employed in environmental studies to trace the movement and transformation of methanol in natural systems. The isotopic labeling allows for the differentiation between naturally occurring and anthropogenic sources of methanol, providing valuable information for environmental monitoring and assessment.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, METHANOL-18O can be utilized for the synthesis of isotopically labeled drugs and drug candidates. This can help in the study of drug metabolism, pharmacokinetics, and the development of more effective and targeted therapeutics.
Used in Analytical Chemistry:
METHANOL-18O serves as a valuable tool in analytical chemistry for the identification and quantification of methanol in various samples. The isotopic labeling enhances the sensitivity and accuracy of analytical techniques, such as mass spectrometry, allowing for more precise measurements and detection limits.
Check Digit Verification of cas no
The CAS Registry Mumber 5770-05-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,7,7 and 0 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 5770-05:
(6*5)+(5*7)+(4*7)+(3*0)+(2*0)+(1*5)=98
98 % 10 = 8
So 5770-05-8 is a valid CAS Registry Number.
5770-05-8Relevant articles and documents
Studies on the B(AL)2 mechanism for esther hydrolysis
Douglas,Campbell,Wigfield
, p. 1841 - 1844 (1993)
The preparation and alkaline hydrolysis of 18O-methyl 2,2-dimethylpropanoate and 18O-methyl triphenylacetate are reported. From mass spectral analysis of the carboxylic acid products, it is concluded that the former substrate is hydrolyzed exclusively by the B(AC)2 mechanism, whereas the latter substrate proceeds 95% by the B(AC)2 mechanism and 5% by the B(AL)2 mechanism. The balance between these two mechanisms is discussed.
Catalytic hydrogenation of CO2from airviaporous silica-supported Au nanoparticles in aqueous solution
Lennox, R. Bruce,Li, Chao-Jun,Ni, Siting,Roy, Ranjan,Zhu, Jun
, p. 3740 - 3749 (2021/06/06)
The conversion of the ubiquitous greenhouse gas CO2to valuable organic products is much sought after. Herein, the hydrogenation of CO2to C1 products with an 80% yield in water is reported using a novel catalyst, porous-silica-supported Au nanoparticles (Au/SiO2). In the presence of a Lewis acid, boric acid, the Au/SiO2catalyst enables an efficient conversion of amine-captured CO2to methanol, formate, and formamide. A mechanistic study involving isotopic labelling suggests that methanol production in the catalytic process arises from the direct hydrogenation of formate. Most importantly, this one-pot, two-step process is able to convert CO2in air at ambient pressures to C1 products in the absence of an organic solvent. Furthermore, the catalyst is readily recycled without further purification or reactivation and shows no significant decrease in catalytic activity after four reaction cycles in a reusability test.
