57711-50-9

Basic information

• Product Name: 3-O-tert-ButyldiMethylsilyl Cholesterol
• Synonyms: 3-O-tert-ButyldiMethylsilyl Cholesterol
• CAS NO: 57711-50-9
• Molecular Formula: C₃₃H₆₀OSi
• Molecular Weight: 500.9144
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 57711-50-9.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• Solubility: Dichloromethane
• CAS DataBase Reference: 3-O-tert-ButyldiMethylsilyl Cholesterol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-O-tert-ButyldiMethylsilyl Cholesterol(57711-50-9)
• EPA Substance Registry System: 3-O-tert-ButyldiMethylsilyl Cholesterol(57711-50-9)

Safety Data

• Hazardous Substances Data: 57711-50-9(Hazardous Substances Data)

Usage

Uses

3-O-tert-Butyldimethylsilyl Cholesterol is a protected derivative of Cholesterol (C432501).

Upstream product

• 57-88-5 cholesterol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 765935-41-9 cholesterol 
• 72726-46-6 tert-butyl(dimethyl)(phenylseleno)silane 
• 2243-09-6 5α-cholestane-3,6-dione 
• 570-85-4 5α-cholestane-3β,6β-diol 
• 540527-34-2 (3S,8S,9S,10R,13R,14S,17R)-3-((tert-butyldimethylsilyl)oxy)-10,13-dimethyl-1-((R)-6-methylheptan-2-yl)-1,2,3,4,8,9,10,11,12,13,14,15,16,17-tetradecahydro-7H-cyclopenta[a]phenanthren-7-one 
• 156809-64-2 3β-<(t-butyldimethylsilyl)oxy>-5α-cholestane-6β-ol 
• 594-19-4 tert.-butyl lithium 
• 142095-81-6 3β-mesityldimethylsilyloxy-5-cholestene 
• 72726-45-5 tert-butyldimethylsilyl iodide 
• 18173-64-3 tert-butyldimethylsilanol 

Downstream Products

• 4351-55-7 cholesteryl formate 
• 604-35-3 Cholesteryl acetate 
• 57-88-5 cholesterol 

Relevant articles and documents

Synthesis of (20S)-[7,7,21,21-2H4]-3β-(tert- butyldimethylsilanyloxy)-20-methyl-pregn-5-en-21-ol, a useful intermediate for the preparation of deuterated isotopomers of sterols

(20S)-[7,7,21,21-2H4]-3β-(tert- Butyldimethylsilanyloxy)-20-methyl-pregn-5-en-21-ol, an intermediate for the preparation of deuterated isotopomers of sterols to be used as standards for biomedical studies, was prepared by reduction with dichloroaluminum deuteride of ethyl (20S)-3β-(tert-butyldimethylsilanyloxy)-7-oxo-pregn-5-en-20-carboxylate. Using controlled experimental conditions, it has also been shown that the dichloroaluminum hydride reduction of a 7-keto steroid affords the corresponding 7β-hydroxy derivative in a highly stereoselective manner.

A new stereospecific approach to steroid side chains: Conversion of dehydroepiandrosterone to cholesterol, isocholesterol, and their 15β-hydroxy derivatives

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HEXADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION

wherein,R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.

A new reagent system for efficient silylation of alcohols: Silyl chloride-N-methylimidazole-iodine

It was found that reactions of alcohols with silyl chlorides in the presence of N-methylimidazole were significantly accelerated by the added iodine, and on this basis a general, and high yielding method for efficient silylation of primary, secondary, and