57717-80-3

Usage

Uses

Used in Pharmaceutical Industry:
CGP 7930 is used as a therapeutic agent for the treatment of substance abuse, particularly targeting nicotine, alcohol, and cocaine addiction. It modulates the GABAergic system, reducing the self-administration of these substances in rodent models and suppressing the acquisition of alcohol drinking behavior in alcohol-na?ve Sardinian alcohol-preferring rats.
Used in Neuropharmacology Research:
CGP 7930 is used as a research tool to study the role of GABAB receptors in the central nervous system. It potentiates the effects of GABAB receptor agonists, such as baclofen and γ-hydroxybutyric acid (GHB), in reducing the spontaneous firing rate of dopaminergic neurons in the rat ventral tegmental area (VTA). This application aids in understanding the mechanisms underlying the regulation of neuronal activity and the potential development of novel treatments for neurological disorders.
Used in Sedative-Reducing Effects:
CGP 7930 is used to enhance the sedative-reducing effects induced by GABAB receptor agonists in rats. When administered at doses ranging from 10 to 170 mg/kg, it potentiates the sedative effects of baclofen and GHB, which can be blocked by the GABAB receptor antagonist SCH 50911. This application is relevant for the development of new sedative agents or the improvement of existing ones.

Biological Activity

Positive allosteric modulator of GABA B receptors. Increases the potency and efficacy of GABA at both native and recombinant GABA B receptors (EC 50 values are 5.37 and 4.60 μ M respectively) and enhances the inhibitory effect of the agonist L-baclofen in cultured cortical neurons. Reduces operant self-administration of ethanol in alcohol-preferring rats following i.p. administration.

InChI:InChI=1/C19H32O2/c1-17(2,3)14-9-13(11-19(7,8)12-20)10-15(16(14)21)18(4,5)6/h9-10,20-21H,11-12H2,1-8H3

Upstream product

• 56189-68-5 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-2,2-dimethyl-propionaldehyde 
• 128-39-2 2,6-di-tert-butylphenol 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 
• 87-97-8 2,6-di-tert-butyl-4-methoxymethylene-phenol 

Downstream Products

• 57717-31-4 (Z)-But-2-enedioic acid bis-[3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2,2-dimethyl-propyl] ester 
• 57717-61-0 Oxalic acid bis-[3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2,2-dimethyl-propyl] ester 
• 57717-09-6 chlorocarbonic acid 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-2,2-dimethylpropyl ester 
• 57717-18-7 Terephthalic acid bis-[3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2,2-dimethyl-propyl] ester 
• 57717-30-3 Phthalic acid bis-[3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2,2-dimethyl-propyl] ester 
• 57717-16-5 2,6-Di-tert-butyl-4-(2,2-dimethyl-3-trimethylsilanyloxy-propyl)-phenol 
• 57717-62-1 Decanedioic acid bis-[3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2,2-dimethyl-propyl] ester 
• 57717-08-5 Thiocarbonic acid O-[3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2,2-dimethyl-propyl] ester O-p-tolyl ester 
• 57717-28-9 [3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2,2-dimethyl-propoxycarbonylmethylsulfanyl]-acetic acid 3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2,2-dimethyl-propyl ester 
• 57717-24-5 Octylsulfanyl-acetic acid 3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2,2-dimethyl-propyl ester 
• 57717-89-2 3-(2-{2-[3-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2,2-dimethyl-propoxycarbonyl]-ethylsulfanyl}-ethylsulfanyl)-propionic acid 3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2,2-dimethyl-propyl ester 
• 57774-19-3 C₄₃H₇₀O₈P₂ 
• 57717-05-2 Carbonic acid 3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2,2-dimethyl-propyl ester octadecyl ester 
• 57717-11-0 3,5-Di-tert-butyl-4-hydroxy-benzoic acid 3-(3,5-di-tert-butyl-4-hydroxy-phenyl)-2,2-dimethyl-propyl ester 

Relevant academic research and scientific papers

Synthesis of 4-(ω-hydroxyalkyl)-2,6-di-tert-butylphenols and the properties of related sulfides

Reaction of 2,6-di-tert-butylphenol with aliphatic linear and branched diols in an alkaline medium at a temperature of 180-220°C leads to the formation of 4-(ω-hydroxyalkyl)-2,6-di-tert-butylphenols. The increase in the product yield and reducing the reaction temperature was reached at the catalysis of this reaction with zinc oxide. The structure of the diphenylalkane derivatives generated in side reaction was proved and the structural influence of the length of the aliphatic residue on the antioxidant effectiveness of the sulfides derived from the corresponding hydroxyalkylphenols was examined.

Synthesis and biological activity of allosteric modulators of GABA B receptors, Part 2. 3-(2,6-Bis-tert-butyl-4-hydroxyphenyl)propanols

A series of 13 2,2-disubstituted 3-(3,5-di-t-butyl-4-hydroxyphenyl)propan- 1-ol derivatives have been prepared for evaluation as allosteric modulators of GABAB receptors. The activity (EC50, 4?7 ?M) was greatest for the cyclohexyl and cyclopentyl analogues. CSIRO 2006.

Preparation of 3-(hydroxyphenyl)propionaldehydes and their hydrogenation to 3-(hydroxyphenyl)propanols

A process for preparing 3-(hydroxyphenyl)propionaldehydes of the formula I STR1 and, where appropriate, for preparing 3-(hydroxyphenyl)propanols of the formula II STR2 where R1, R2, R3 and R4 are each hydrogen,

Phosphite ester stabilizers

Compounds of the formula I STR1 in which R1 and R2 independently of one another denote alkyl, cycloalkyl or aralkyl, R3 denotes hydrogen or, conjointly with R1, denotes tetramethylene, R4 denotes hydr

Antioxidant ester substituted phenols and process for their preparation

This invention comprises an alkylation, reduction and transesterification process for the preparation of ester substituted phenols. The products are useful as antioxidants and may be prepared in high yields and with a high degree of purity.