57731-88-1

Upstream product

• 68200-72-6 N⁶-benzoyl-5'-deoxy-5'-iodo-2',3'-O-isopropylideneadenosine 
• 98-88-4 benzoyl chloride 
• 40982-79-4 N⁶,N⁶-dibenzoyl-5'-O-mesyl-2',3'-O-isopropylidene adenosine 
• 39947-04-1 N-6-benzoyl-2',3'-O-isopropylideneadenosine 
• 67662-04-8 N-benzoyl-N-(9-(6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)-9H-purin-6-yl)benzamide 
• 362-75-4 2',3'-isopropylidene adenosine 

Downstream Products

• 57731-94-9 N⁶-benzoyl-O^2'_,O3'-isopropylidene-8,5'-cyclo-5'-deoxy-adenosine 
• 57731-96-1 (8Ξ)-N⁶-benzoyl-O^2',O^3'-isopropylidene-7,8-dihydro-8,5'-cyclo-5'-deoxy-adenosine 
• 57731-92-7 5',8-Cyclo-5'-deoxy-2',3'-O-isopropylidene-6-,N'-dibenzoyl-adenosine 
• 57731-93-8 (8Ξ)-N⁶,N⁶-dibenzoyl-O^2',O^3'-isopropylidene-7,8-dihydro-8,5'-cyclo-5'-deoxy-adenosine 
• 57731-96-1 C₂₀H₂₁N₅O₄ 
• 75765-67-2 O-isopropylidene-2',3' N,N'-dibenzoyl-6 dihydro-7,8 cyclo-5',8 desoxy-5 adenosine 
• 57731-95-0 cyclo-5'8 desoxy-5' O-isopropylidene-2',3' adenosine 
• 87884-15-9 9--6-cyano-5,6,7,8,9-pentadeoxy-2,3-O-isopropylidene-β-D-ribo-deca-6-enofuranosyluronate>-adenine 
• 50466-88-1 1-(6-benzoylamino-purin-9-yl)-6-diethoxyphosphoryl-O²,O³-isopropylidene-1,5,6-trideoxy-heptofuranurononitrile 

Relevant academic research and scientific papers

Structure of the epigenetic oncogene MMSET and inhibition by N-alkyl sinefungin derivatives

The members of the NSD subfamily of lysine methyl transferases are compelling oncology targets due to the recent characterization of gain-of-function mutations and translocations in several hematological cancers. To date, these proteins have proven intrac

New aspects on the reactivity of radicals generated from 5′-deoxy-5′-iodoadenosine derivatives

Acrylonitrile can serve as a trap for a 5′-centered radical derived from adenosine affording the corresponding three carbon extended adenosine derivative 8 together with the known 5′,8-cyclization product 9.

Synthetic Approaches towards Nucleocidin and Selected Analogues; anti-HIV Activity in 4'-Fluorinated Nucleoside Derivatives

Nucleocidin 1 has been synthesised from the adenosine derivative 4 via the intermediacy of the dihalogeno compound 9.The latter compound showed slight but significant activity against HIV-infected cells while the isomer 10 and the monohalogeno compound 60 were inactive.Synthetic approaches towards other 4'-fluorinated nucleoside derivatives are also described.The epimeric 4'-fluorinated nucleosides 26 and 27 displayed similar activity against HIV-infected cells to that observed for the dihalogenated compound 9.

SYNTHESE DE LA CYCLO-5'-8 DESOXY-5' ADENOSINE: STEREOCHIMIE ET MECHANISME DE LA CYCLISATION D'UN DERIVE DE L'IODO-5' ADENOSINE PAR LE ZINC

N,N'-Dibenzoyl 2',3'-O-isopropylidene 5'-deoxy 5'-iodo adenosine can efficiently transformed into the corresponding 5',8-cyclo-7,8-dihydronucleoside by zinc in pyridine.Only one diastereoisomer is obtained.By spin decoupling and NOE techniques at 250 MHz,