5778-86-9

Basic information

• Product Name: 11-AMINO-7,8,9,10-TETRAHYDRO-6H-CYCLOHEPTA[B]QUINOLINE
• Synonyms: 11-AMINO-7,8,9,10-TETRAHYDRO-6H-CYCLOHEPTA[B]QUINOLINE;6H-Cyclohepta[b]quinolin-11-aMine, 7,8,9,10-tetrahydro-
• CAS NO: 5778-86-9
• Molecular Formula: C14H16N2
• Molecular Weight: 212.294
• Mol File: 5778-86-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 420.3°Cat760mmHg
• Flash Point: 237.5°C
• Appearance: /
• Density: 1.156g/cm³
• Vapor Pressure: 2.84E-07mmHg at 25°C
• Refractive Index: 1.66
• CAS DataBase Reference: 11-AMINO-7,8,9,10-TETRAHYDRO-6H-CYCLOHEPTA[B]QUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 11-AMINO-7,8,9,10-TETRAHYDRO-6H-CYCLOHEPTA[B]QUINOLINE(5778-86-9)
• EPA Substance Registry System: 11-AMINO-7,8,9,10-TETRAHYDRO-6H-CYCLOHEPTA[B]QUINOLINE(5778-86-9)

Safety Data

• Hazardous Substances Data: 5778-86-9(Hazardous Substances Data)

Usage

General Description

11-AMINO-7,8,9,10-TETRAHYDRO-6H-CYCLOHEPTA[B]QUINOLINE is a chemical compound with a bicyclic structure consisting of a seven-membered ring fused to a six-membered ring. It contains an amino group at the 11th position and is classified as a quinoline derivative. 11-AMINO-7,8,9,10-TETRAHYDRO-6H-CYCLOHEPTA[B]QUINOLINE is a versatile building block in organic synthesis and has been used in the preparation of various pharmaceuticals and biologically active molecules. It exhibits potential pharmacological activities, making it a valuable intermediate in the development of new drug candidates. Additionally, it has been studied for its potential use in the treatment of various diseases and disorders due to its structural features and biological activities.

InChI:InChI=1/C14H16N2/c15-14-10-6-2-1-3-8-12(10)16-13-9-5-4-7-11(13)14/h4-5,7,9H,1-3,6,8H2,(H2,15,16)

Upstream product

• 1885-29-6 anthranilic acid nitrile 
• 502-42-1 cycloheptanone 

Downstream Products

• 108154-83-2 4-n-Hexylamino-2,3-pentamethylenequinoline hydrochloride 
• 28869-39-8 4-n-Butylamino-2,3-pentamethylenequinoline hydrochloride 

Relevant articles and documents

Design, Synthesis and Biological Evaluation of New Cycloalkyl Fused Quinolines Tethered to Isatin Schiff Bases as Cholinesterase Inhibitors

Aims and Objective: Alzheimer’s disease is now a most prevalent neurodegenerative disease of central nervous system leading to dementia in elderly population. Numerous pathological changes have been associated in the progression of Alzheimer’s disease. On

Novel tacrine analogues for potential use against Alzheimer's disease: Potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitors

Several novel analogues of tactine have been synthesized and tested for their ability to inhibit acetylcholinesterase, butyrylcholinesterase, and neuronal uptake of 5-HT (serotonin) and noradrenaline. Changes in the size of the carbocyclic ring of tactine produced modest potency against cholinesterase enzymes. Addition of a fourth ring resulted in compounds with marked selectivity for acetylcholinesterase (AChE) over butyrylcholinesterase [BChE): e.g. 6-amino-4,5-benzo-5H-cyclopenta[1,2-b]-quinoline (14a) had an IC50 of 0.35μM against AChE and 3.1 μM against BChE. Some tetracyclic compounds are 100-400 times more active than tacrine as inhibitors of neuronal uptake of serotonin, in particular 13-amino-6,7-dihydro-5H- benzo[3,4]cyclohepta[1,2-b]quinoline (18), which had an IC50 of 20 nM. These compounds would be expected to facilitate both cholinergic and monoaminergic transmission. They should be worth investigating in models of memory impairment.