577954-86-0 Usage
Uses
Used in Pharmaceutical Synthesis:
3'-Chloro-4'-fluoro-2-biphenylamine is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity make it a valuable component in the development of new drugs and medications.
Used in Organic Compound Synthesis:
In addition to its pharmaceutical applications, 3'-chloro-4'-fluoro-2-biphenylamine is also used as a building block in the synthesis of other organic compounds. Its halogenated nature allows for further chemical reactions and modifications, contributing to the creation of a wide range of chemical products.
Used in Chemical Research:
3'-Chloro-4'-fluoro-2-biphenylamine is utilized in chemical research to study the properties and reactions of halogenated biphenyls. Understanding its reactivity and behavior in various chemical contexts can lead to the discovery of new applications and uses in different industries.
Check Digit Verification of cas no
The CAS Registry Mumber 577954-86-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,7,7,9,5 and 4 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 577954-86:
(8*5)+(7*7)+(6*7)+(5*9)+(4*5)+(3*4)+(2*8)+(1*6)=230
230 % 10 = 0
So 577954-86-0 is a valid CAS Registry Number.
577954-86-0Relevant articles and documents
N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling
Lai, Mei-Jung,Lee, Hsueh-Yun,Chuang, Hsun-Yueh,Chang, Li-Hsun,Tsai, An-Chi,Chen, Mei-Chuan,Huang, Han-Lin,Wu, Yi-Wen,Teng, Che-Ming,Pan, Shiow-Lin,Liu, Yi-Min,Mehndiratta, Samir,Liou, Jing-Ping
, p. 6549 - 6558 (2015)
A series of N-sulfonyl-aminobiaryl derivatives have been examined as novel antitubulin agents. Compound 21 [N-(4′-cyano-3′-fluoro-biphenyl-2-yl)-4-methoxy-benzenesulfonamide] exhibits remarkable antiproliferative activity against four cancer cell lines (pancreatic AsPC-1, lung A549, liver Hep3B, and prostate PC-3) with a mean GI50 value of 57.5 nM. Additional assays reveal that 21 inhibits not only tubulin polymerization but also the phosphorylation of STAT3 inhibition with an IC50 value of 0.2 μM. Four additional compounds (8, 10, 19, and 35) are also able to inhibit this phosphorylation. This study describes novel N-sulfonyl-aminobiaryl (biaryl-benzenesulfonamides) as potent anticancer agents targeting both STAT3 and tubulin. (Chemical Equation Presented).
