57796-25-5

Upstream product

• 26116-12-1 1-ethyl-2-pyrrolidinemethanamine 
• 7440-44-0 pyrographite 
• 57796-33-5 6-chloro-5-ethylamino-3-methoxy-pyrazine-2-carboxylic acid 
• 57796-14-2 6-chloro-5-ethylamino-3-methoxy-pyrazine-2-carboxylic acid methyl ester 

Downstream Products

• 57796-45-9 6-benzylsulfanyl-5-ethylamino-3-methoxy-pyrazine-2-carboxylic acid (1-ethyl-pyrrolidin-2-ylmethyl)-amide 

Relevant academic research and scientific papers

Pyrazine derivatives

Pyrazine derivatives by the formula STR1 are disclosed. In the above formula, R1 and R2, which may be the same or different, each represents a hydrogen atom, a halogen atom, a hydroxy group, a lower alkoxy group, a phenyl lower alkoxy group, a phenoxy group, a mercapto group, a lower alkylthio group, a phenyl lower alkylthio group, a phenylthio group, an amino group, a substituted amino group, a lower alkyl group, a carbamoyl group or a sulfamoyl group; R3 represents a lower alkoxy group; R4, R5, and R6, which may be the same or different, each represents a hydrogen atom, a lower alkyl group, a cycloalkyl group, a phenyl lower alkyl group, or a phenyl group; and A represents a lower alkylene group; said R4 and A, said R5 and A, said R4 and R5, or said R5 and R6 may form a 5-membered or 6-membered nitrogen-containing heterocyclic ring which may further contain a hetero-atom together with nitrogen atom, and the pharmacologically acceptable non-toxic salts thereof. The compounds of this invention have a strong and selective antiematic activity and an effect of stimulating the gastric motility.