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Usage

Uses

Used in Pharmaceutical Research and Drug Development:
1-(2-amino-5-(trifluoromethyl)phenyl)ethanone is used as a building block for the synthesis of bioactive molecules, contributing to the development of new therapeutics. Its unique structure, which includes a trifluoromethyl group, an amino group, and a phenyl group, allows for a wide range of applications in creating novel pharmaceutical compounds.
Used in Organic Synthesis and Medicinal Chemistry:
In addition to its role in pharmaceutical research, 1-(2-amino-5-(trifluoromethyl)phenyl)ethanone is also utilized in the fields of organic synthesis and medicinal chemistry. Its versatile structure enables it to be a key component in the creation of various organic compounds, further expanding its potential applications.

Upstream product

• 6526-08-5 2-amino-5-(trifluoromethyl)benzonitrile 
• 75-16-1 methylmagnesium bromide 
• 163444-17-5 2-iodo-4-(trifluoromethyl)aniline 
• 878133-02-9 2-ethynyl-4-(trifluoromethyl)aniline 
• 440363-04-2 2-(2-trimethylsilylethynyl)-4-trifluoromethylaniline 

Relevant academic research and scientific papers

Pd-catalyzed regiodivergent synthesis of diverse oxindoles enabled by the versatile heck reaction of carbamoyl chlorides

We report herein a miscellaneous oxindole synthesis bearing an all-carbon quaternary center, enabled by Pd-catalyzed intramolecular cyclization followed by multiple intermolecular Heck reactions of both easily accessible alkene-tethered carbamoyl chlorides and olefins. This protocol obviates the use of prefunctionalized olefinic reagents, exhibits excellent functional group tolerance, and features fascinating reactive versatility.

Copper-Catalyzed Chemoselective Cyclization Reaction of 2-Isocyanoacetophenone: Synthesis of 4-Hydroxyquinoline Compounds

A copper-catalyzed intramolecular cyclization reaction of 2-isocyanoacetophenone derivatives to afford 4-hydroxyquinolines chemoselectively is described. The transformation proceeds through enol tautomerism and a subsequent C-C bond formation. Compared to previous methods, this study provides a new protocol for the construction of 4-hydroxyquinoline compounds from functionalized isocyanides under mild conditions.

Trifluoromethyl-promoted homocamptothecins: Synthesis and biological activity

The homocamptothecin (hCPT) represents a new class of topoisomerase inhibitor which combines enhanced plasma stability and strong antitumor activity. Fluorine imparts desirable characteristics to drugs by modulating both the pharmacokinetics and pharmacodynamic properties of a drug. Therefore, in an attempt to improve the antitumor activity of homocamptothecins, seven new 7-trifluoromethylated homocamptothecin derivatives were prepared by proline-catalyzed Friedlander annulation. The antitumor activity in vitro and in vivo on cancer cell lines, and inhibitory properties of topoisomerase I-mediated DNA cleavage of compounds 6c and 8b were evaluated. Several of these trifluoromethylated hCPT derivatives (such as 6a, 6b and 6c) possessed higher in vitro antitumor activity than topotecan (TPT). Especially, the compound 6c showed effective in vivo antitumor activity comparable to that of TPT.