578-96-1Relevant articles and documents
Synthesis of Pyrido-Fused Quinazolinone Derivatives via Copper-Catalyzed Domino Reaction
Liu, Meilin,Shu, Miaomiao,Yao, Chaochao,Yin, Guodong,Wang, Dunjia,Huang, Jinkun
supporting information, p. 824 - 827 (2016/03/04)
A simple and efficient synthesis of 11H-pyrido[2,1-b]quinazolin-11-ones by Cu(OAc)2·H2O-catalyzed reaction of easily available substituted isatins and 2-bromopyridine derivatives has been developed. The reaction involves C-N/C-C bond cleavage and two C-N bond formations in a one-pot operation. This methodology is complementary to previously reported synthetic procedures, and two plausible reaction mechanisms are discussed. (Chemical Equation Presented).
Synthesis of α-carbolines starting from 2,3-dichloropyridines and substituted anilines
Hostyn, Steven,Van Baelen, Gitte,Lemiere, Guy L. F.,Maes, Bert U. W.
supporting information; scheme or table, p. 2653 - 2660 (2009/08/14)
9H-α-Carbolines have been prepared via consecutive intermolecular Buchwald-Hartwig reaction and Pd-catalyzed intramolecular direct arylation from commercially available 2,3-dichloropyridines and substituted anilines. The combination of a high reaction temperature (180°C) and the use of DBU were found to be crucial for the intramolecular direct arylation reactions of the 3-chloro-N-phenylpyridin-2-amines as no reaction was observed at 120°C and 180°C using different inorganic and other organic bases. On the other hand, nitrogen-methylated pyridine analogues of these substrates {N-[3-chloro-1- methylpyridin-2(1H)-ylidene]anilines} do undergo ring closure at 120°C, with K3PO4 as base, affording the respective 1-methyl-1H-α-carbolines in good yields.
