578-96-1

Usage

Uses

Used in Medicinal Chemistry:
11H-pyrido(2,1-b)quinazolin-11-one is used as a key intermediate in the synthesis of various pharmaceutical compounds for its structural properties and potential biological activities. Its unique ring system allows for the development of new drugs with specific therapeutic targets.
Used in Drug Development:
In the pharmaceutical industry, 11H-pyrido(2,1-b)quinazolin-11-one is utilized as a lead compound for the discovery and optimization of novel therapeutic agents. Its structural features enable the design of drugs with improved potency, selectivity, and pharmacokinetic properties, making it a valuable asset in the drug development process.
Used in Anticancer Research:
11H-pyrido(2,1-b)quinazolin-11-one is employed as a potential anticancer agent in cancer research. Its ability to interact with specific biological targets, such as enzymes or receptors involved in cancer cell growth and proliferation, makes it a promising candidate for the development of new cancer therapies.
Used in Drug Design and Optimization:
In the field of drug design, 11H-pyrido(2,1-b)quinazolin-11-one serves as a valuable template for the creation of new drug candidates. Its structural properties can be modified and optimized to enhance the drug's efficacy, safety, and pharmacological profile, leading to the development of more effective treatments for various diseases.
Overall, 11H-pyrido(2,1-b)quinazolin-11-one is a versatile chemical compound with significant potential in various applications across the pharmaceutical and medicinal chemistry industries. Its unique structure and biological activities make it an important tool for drug discovery, development, and optimization, as well as a promising candidate for the treatment of various diseases, including cancer.

InChI:InChI=1/C12H8N2O/c15-12-9-5-1-2-6-10(9)13-11-7-3-4-8-14(11)12/h1-8H

Upstream product

• 40352-87-2 2,1-benzisothiazolin-3(1H)-one 
• 109-09-1 2-chloropyridine 
• 91-56-5 indole-2,3-dione 
• 504-29-0 2-aminopyridine 
• 18698-97-0 ortho-bromophenylacetic acid 
• 1446208-21-4 2-(2-bromophenyl)-N-(pyridin-2-yl)acetamide 
• 2402-77-9 2,3-dichloro-pyridine 
• 87-25-2 2-ethoxycarbonylaniline 
• 91859-91-5 2,1-benzisothiazoline-3-spiro-2',4'-oxo-4'H-3',1'-benzoxazolidine 
• 118-92-3 anthranilic acid 

Downstream Products

• 2446-62-0 7,8,9-trihydropyrido[2,1-b]quinazolin-11(6H)-one 
• 51440-34-7 N-pyridylanthranilic acid 
• 6631-37-4 2-(phenylamino)pyridine 
• 84-26-4 rutaecarpine 
• 80776-66-5 6-phenylhydrazono-6,7,8,9-tetrahydro-11H-pyrido<2,1-b>quinazolin-11-one 
• 1609121-18-7 3-(2-(pyridin-2-ylamino)phenyl)pentan-3-ol 
• 1609121-17-6 (2-(pyridin-2-ylamino)phenyl)methanol 
• 86-96-4 1,2,3,4-tetrahydro-quinazoline-2,4-dione 

Relevant academic research and scientific papers

Synthesis of Pyrido-Fused Quinazolinone Derivatives via Copper-Catalyzed Domino Reaction

A simple and efficient synthesis of 11H-pyrido[2,1-b]quinazolin-11-ones by Cu(OAc)2·H2O-catalyzed reaction of easily available substituted isatins and 2-bromopyridine derivatives has been developed. The reaction involves C-N/C-C bond cleavage and two C-N bond formations in a one-pot operation. This methodology is complementary to previously reported synthetic procedures, and two plausible reaction mechanisms are discussed. (Chemical Equation Presented).

Copper-catalyzed aerobic oxidative annulation and carbon-carbon bond cleavage of arylacetamides: Domino synthesis of fused quinazolinones

An efficient copper-catalyzed tandem aerobic oxidative annulation and carbon-carbon bond cleavage reaction was developed from easily accessible arylacetamides, which provides a direct approach for the domino synthesis of a vast array of tricyclic or tetracyclic fused quinazolinone alkaloid structures. A plausible reaction mechanism is proposed involving an aerobic benzylic oxidation/ cyclization/decarbonylation cascade.

Synthesis of α-carbolines starting from 2,3-dichloropyridines and substituted anilines

9H-α-Carbolines have been prepared via consecutive intermolecular Buchwald-Hartwig reaction and Pd-catalyzed intramolecular direct arylation from commercially available 2,3-dichloropyridines and substituted anilines. The combination of a high reaction temperature (180°C) and the use of DBU were found to be crucial for the intramolecular direct arylation reactions of the 3-chloro-N-phenylpyridin-2-amines as no reaction was observed at 120°C and 180°C using different inorganic and other organic bases. On the other hand, nitrogen-methylated pyridine analogues of these substrates {N-[3-chloro-1- methylpyridin-2(1H)-ylidene]anilines} do undergo ring closure at 120°C, with K3PO4 as base, affording the respective 1-methyl-1H-α-carbolines in good yields.

2,1-Benzisothiazoles. XIII . Intermediates and Products in the Sulfur Extrusion Reaction of 2,1-Benzisothiazolines-3(1H)-one. A New Synthesis of 11H-Pyridoquinazolin-11-one ("Pyracridone")

Triethyl phosphite abstracts sulfur from 2,1-benzisothiazolin-3(1H)-one (1); a reaction intermediate is the spirocyclic compound 11, and products include the benzoxazine 6 and polyanthraniloyl compounds.In the presence of pyridine, pyracridone (13) is formed.The ketene-imine 9 is probably not an intermediate in these reactions.The reactions of other nucleophiles with 1 and with its N-methyl derivative 15, have been examined.