5783-01-7Relevant academic research and scientific papers
Direct: N -alkylation of sulfur-containing amines
Li, Chen,Ge, Min-Tong,Bai, Liang,Xia, Ai-Bao,Xu, Dan-Qian,Xu, Zhen-Yuan
supporting information, p. 4478 - 4482 (2021/05/31)
An efficient ruthenium-catalyzed method has been developed for the direct N-alkylation of sulfur-containing amines with alcohols, for the first time, by a step-economical and environmentally friendly hydrogen borrowing strategy. The present methodology features base-free conditions and broad substrate scope, with water being the only by-product. Moreover, this protocol has been applied to the synthesis of the pharmaceutical drug Quetiapine.
Application of bis(triphenylphosphine)carbonyl ruthenium dichloride monohydrate
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Paragraph 0142-0144, (2021/07/10)
The invention provides bis(triphenylphosphine)carbonyl ruthenium dichloride monohydrate. A preparation method comprises the following steps: adding triphenylphosphine into an organic solvent A, and conducting heating to 50-100 DEG C to dissolve the triphenylphosphine so as to obtain a solution A; adding ruthenium trichloride into an organic solvent B, and conducting dissolving to obtain a solution B; then sequentially and rapidly adding the solution B and an aqueous formaldehyde solution with a mass fraction of 37% into the solution A, and conducting a reaction for 0.5-2 h at a temperature of 80-130 DEG C; and carrying out post-treatment on the obtained reaction solution A to obtain the bis(triphenylphosphine)carbonyl ruthenium dichloride monohydrate. Compared with a synthesis method proposed by Colt and the like, the method disclosed by the invention has the advantages that the use of strong acid can be well avoided, injury to operators in an experiment process is reduced, reaction time is greatly shortened, treatment after the experiment is simple, and experiment efficiency is improved.
Preparation method of bis(triphenylphosphine) carbonyl ruthenium dichloride monohydrate
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Paragraph 0145-0147, (2021/08/06)
The invention provides bis(triphenylphosphine) carbonyl ruthenium dichloride monohydrate, which is prepared by the following steps of adding triphenylphosphine into an organic solvent A, and heating to 50-100 DEG C to dissolve the triphenylphosphine to obtain a solution A, adding ruthenium trichloride into an organic solvent B, and dissolving to obtain a solution B, then sequentially and rapidly adding the solution B and a formaldehyde aqueous solution with the mass fraction of 37% into the solution A, and conducting a reaction for 0.5-2 h at the temperature of 80-130 DEG C, and carrying out post-treatment on the obtained reaction liquid A to obtain the bis(triphenylphosphine) carbonyl ruthenium dichloride monohydrate. Compared with a synthesis method of Colt et al., the method disclosed by the invention has the advantages that the use of strong acid can be well avoided, the injury to operators in the experiment process is reduced, the reaction time is greatly shortened, the treatment after the experiment is simple, and the experiment efficiency is improved.
