578703-91-0

Upstream product

• 67-56-1 methanol 
• 113934-27-3 1-(4-chlorophenyl)-1H-1,2,3-triazole-4-carbaldehyde 
• 3296-05-7 1-azido-4-chlorobenzene 
• 922-67-8 propynoic acid methyl ester 
• 34846-90-7 methyl 3-methoxyprop-2-enoate 
• 1189781-14-3 C₈H₁₁N₃O₂ 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 578703-73-8 1-(4-chlorophenyl)-1H-1,2,3-triazole-4-carbohydrazide 

Relevant academic research and scientific papers

Direct access to 1,4-disubstituted 1,2,3-triazoles through organocatalytic 1,3-dipolar cycloaddition reaction of α,β-unsaturated esters with azides

DBU-catalyzed organocatalytic 1,3-dipolar cycloaddition reactions of α,β-unsaturated esters with azides have been developed. This strategy generates 1,4-disubstituted 1,2,3-triazoles in high yields with high regioselectivities. It is demonstrated that some of these products can be transformed into important pharmaceutical agents.

Hyperbranched polyethylenimine-supported copper(II) ions as a macroliganted homogenous catalyst for strict click reactions of azides and alkynes in water

Loading hyperbranched polyethylenimine (PEI) with copper(II) ions leads to the formation of a new water-soluble metallodendritic polymer Cu(II)-PEI that has been found to effectively catalyze the clickable azide-alkyne [3 + 2] cycloaddition reactions in w

Silver(I) oxide nanoparticles as a catalyst in the azide-alkyne cycloaddition

1,3-Dipolar cycloadditions between a number of azides and monosubstituted acetylenes have been carried out in the presence of catalytic amounts of silver(I) oxide nanoparticles. 4-Substituted 1,2,3-triazoles were usually the only products, while the prese

'Click' chemistry on sugar-derived alkynes: A tandem 'click-click' approach to bistriazoles

Development of a tandem 'click-click' approach to the formation of successive 1,4-disubstituted 1,2,3-triazole linkages and 'click chemistry' on sugar-derived alkynes are described. Georg Thieme Verlag Stuttgart.

Arylazide cycloaddition to methyl propiolate: DFT-based quantitative prediction of regioselectivity

Several 1-(4-substituted)-phenyl-4- or 5-methoxycarbonyl-1,2,3-triazoles have been synthesized by 1,3-dipolar cycloaddition of the corresponding arylazides to methyl propiolate in carbon tetrachloride. The regioselectivity of these reactions cannot be rat

Antiplatelet properties of novel N-substituted-phenyl-1,2,3-triazole-4-acylhydrazone derivatives

This paper describes the design, synthesis and pharmacological evaluation of new N-acylhydrazone (NAH) compounds, belonging to the N-substituted-phenyl-1,2,3-triazole-4-acylhydrazone class (2a-p). Classical heteroaromatic ring bioisosterism strategies wer