57880-71-4

Upstream product

• 79-36-7 dichloroacethyl chloride 
• 836-41-9 p-methoxybenzylidene-phenylamine 
• 598-99-2 Methyl trichloroacetate 
• 40339-47-7 (Z)-1-(4-methoxyphenyl)-N-phenylmethanimine 
• 25436-07-1 trimethylsilyl trichloroacetate 
• 4124-31-6 trichloroacetic acid anhydride 
• 1613-96-3 N-(4-methoxybenzylidene)aniline 
• 62-53-3 aniline 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 41448-64-0 1-(2,2-dichlorovinyl)-4-methoxybenzene 
• 4591-28-0 dichloroketene 
• 103-71-9 phenyl isocyanate 
• 836-41-9 p-methoxybenzylidene-phenylamine 

Relevant academic research and scientific papers

3,3-Dichloro-4-(p-methoxyphenyl)-1-phenyl-2-azetidinone

The structure of the title compound consists of discrete C16H13Cl2NO2 molecules with a closest intermolecular contact of 2.54 (3) angstroms between the carbonyl O atom and a methyl H atom. The four-membered ring is nearly planar, with long C-C distances of 1.564 (5) and 1.537 (5) angstroms, similar to the distances observed in other substituted monocyclic β-lactams. The dihedral angle between the planes of the phenyl rings is 78.6 (1)°.

Synthesis and antimicrobial activity of 1,4-diaryl-2-azetidinones

Cycloaddition of substituted 4,4-benzylidene-anilines to in situ prepared dichloroketenes in the presence of dichloroacetyl chloride and triethylamine affords a variety of 2-azetidinones. All the compounds were characterized by IR and 1H NMR. Their antimicrobial activity, against Gram(+) and Gram(-) bacteria and fungi, was tested. Copyright (C) 2000 Elsevier Science S.A.

Reaction of Imines with Trichloroacetic Esters or Anhydride Promoted by Iron Carbonyl or Microwave Irradiation. Preparation of 3,3-Dichloro-β-Lactams

The synthesis of 3,3-dichloroazetidin-2-ones by the reaction of imines and methyl or trimethylsilyl trichloroacetate promoted by diiron nonacarbonyl or by microwave irradiation of imines and trichloroacetic anhydride is described.