57894-15-2

Basic information

• Product Name: N-(3,4-dihydroxy-benzyl)-benzamide
• CAS NO: 57894-15-2
• Molecular Weight: 243.262
• Mol File: 57894-15-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(3,4-dihydroxy-benzyl)-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,4-dihydroxy-benzyl)-benzamide(57894-15-2)
• EPA Substance Registry System: N-(3,4-dihydroxy-benzyl)-benzamide(57894-15-2)

Safety Data

• Hazardous Substances Data: 57894-15-2(Hazardous Substances Data)

Upstream product

• 6282-02-6 N-(hydroxymethyl)benzamide 
• 120-80-9 benzene-1,2-diol 
• 16290-26-9 3,4-dihydroxybenzylamine hydrobromide 
• 65-85-0 benzoic acid 

Relevant articles and documents

Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF

Catechol-based inhibitors of ERCC1-XPF endonuclease activity were identified from a high-throughput screen. Exploration of the structure-activity relationships within this series yielded compound 13, which displayed an ERCC1-XPF IC50 of 0.6 μM, high selectivity against FEN-1 and DNase I and activity in nucleotide excision repair, cisplatin enhancement and γH2AX assays in A375 melanoma cells. Screening of fragments as potential alternatives to the catechol group revealed that 3-hydroxypyridones are able to inhibit ERCC1-XPF with high ligand efficiency, and elaboration of the hit gave compounds 36 and 37 which showed promising ERCC1-XPF IC50 values of 10 μM.