57915-83-0Relevant academic research and scientific papers
Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction
Mahalingam, Poornachandran,Takrouri, Khuloud,Chen, Ting,Sahoo, Rupam,Papadopoulos, Evangelos,Chen, Limo,Wagner, Gerhard,Aktas, Bertal H.,Halperin, Jose A.,Chorev, Michael
, p. 5094 - 5111 (2014/07/08)
The 4EGI-1 is the prototypic inhibitor of eIF4E/eIF4G interaction, a potent inhibitor of translation initiation in vitro and in vivo and an efficacious anticancer agent in animal models of human cancers. We report on the design, synthesis, and in vitro ch
COMPOUNDS FOR THE INHIBITION OF CELLULAR PROLIFERATION
-
Page/Page column 93-95, (2012/02/01)
Compositions and methods for inhibiting translation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, (4) disorders associated with viral infections, and/or (5) non-proliferative metabolic disorders such as type II diabetes where inhibition of translation initiation is beneficial using the compounds disclosed herein.
Synthesis and β-adrenergic properties of tetrahydronaphthalene analogs of dichloroisoproterenol
Balsamo, A.,Breschi, M. C.,Giannaccini, G.,Lapucci, A.,Lucacchini, A.,et al.
, p. 735 - 742 (2007/10/02)
The tetrahydronaphthalene analogs 4 an 5 of DCl (3b) and of its N-unsubstituted derivative (3a) were synthesized and tested for their β-adrenergic properties by means of both binding tests and functional tests.Compounds 4 and 5 proved to possess a good affinity for β-adrenergic receptors accompanied by an appreciable β-blocking activity, thus indicating that the formal insertion of a β-blocking drug such as DCl into a tetrahydronaphthalene structure is able to provide compounds which still possess a β-blocking activity. adrenergic drugs / 3-blocking agents /dichloroisoproterenol cyclic analogs / tetrahydronaphthalene derivatives
