579486-76-3Relevant academic research and scientific papers
Active site directed inhibitors of replication-specific bacterial DNA polymerases
Wright, George E.,Brown, Neal C.,Xu, Wei-Chu,Long, Zheng-Yu,Zhi, Chengxin,Gambino, Joseph J.,Barnes, Marjorie H.,Butler, Michelle M.
, p. 729 - 732 (2005)
7-Substituted-N2-(3,4-dichlorobenzyl)guanines potently and competitively inhibit DNA polymerases IIIC and IIIE from Gram+ bacteria. Certain derivatives are also competitive inhibitors of DNA polymerase IIIE from Gram- bacteria.
Purine and isosteric antibacterial compounds
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Page/Page column 10; 14, (2010/02/05)
The invention features 2,7-disubstituted purines and their isosteres such as the corresponding 3-deazapurines and 3-deaza-8-azapurines. The compounds disclosed herein have potent anti-microbial, e.g., anti-bacterial and anti-mycoplasmal properties. The compounds described herein inhibit DNA polymerase IIIC and DNA polymerase IIIE species; the compounds thus inhibit the growth of bacteria and mycoplasmata. The compounds can be administered to prevent or to treat Gram-positive or Gram-negative bacterial or mycoplasmal infections, e.g., in eukaryotic cell cultures, animals, or humans.
