57962-52-4

Usage

Type of compound

Tertiary amine

Structural features

Contains a benzyl ether group
Contains a hydroxyl group

Applications

Reagent in organic synthesis
Chiral auxiliary in asymmetric synthesis
Building block in the pharmaceutical industry for the synthesis of various drugs and bioactive compounds

Potential therapeutic use

Studied for its potential use in the treatment of asthma and other respiratory conditions.

Upstream product

• 100-39-0 benzyl bromide 
• 2930-05-4 Benzyloxymethyl-oxiran 
• 74-89-5 methylamine 

Downstream Products

• 113681-82-6 N-(3-Benzyloxy-2-hydroxy-propyl)-2-(5-fluoro-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-N-methyl-acetamide 
• 930118-51-7 (3-benzyloxy-2-hydroxy-propyl)-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester 

Relevant academic research and scientific papers

Towards a biomimetic poly-aminoketone foldamer: synthesis of a triply protected monomer and its coupling to a dimer, trimer and tetramer

The design of a new biomimetic foldamer, relying on the weak amine-carbonyl interaction for secondary structure formation, is presented. The efficient synthesis of a triply protected monomer starting from glycidol was developed. This monomer contains a dioxolane-protected keto group that will allow liberation of the ketone functionality in the backbone once construction of the oligomeric backbone is complete. This monomer contains two additional orthogonal protecting groups at its two termini, the Fmoc and the TBDMS groups. The Fmoc group in particular permits oligomerisation towards the N terminus as seen in Fmoc solid phase peptide synthesis. Construction and full characterisation of a ketone-protected dimer, trimer and tetramer are reported.

HYDROPHILIC 1-(CARBOXYMETHYL)-5-FLUOROURACIL AMIDES: PREPARATION AND CYTOSTATIC ACTIVITY

The following N-substituted amides IV were prepared by reaction of 1-(carboxymethyl)-5-fluorouracil p-nitrophenyl ester (II) with primary or secondary hydroxyalkylamines III: 2-hydroxypropyl (IVa), 3-hydroxypropyl (IVb), 2,3-dihydroxypropyl (IVc), 3-hydroxy-2-methyl-2-propyl (IVd), 1,3-dihydroxy-2-propyl (IVe), 1-deoxyglucitol-1-yl (IVg), 2-deoxyglucitol-2-yl (IVh), methyl-2,3-dihydroxypropyl (IVi), methyl-1-deoxyglucitol-1-yl (IVk), and n-butyl-2,3-dihydroxypropyl(IVl).None of these compounds had any cytostatic activity towards murine leukemia L-1210 cell growth in a tissue culture at 10-5 mol l-1.