57965-22-7

Usage

InChI:InChI=1/C10H7F3O3/c11-10(12,13)9(16)5-8(15)6-1-3-7(14)4-2-6/h1-4,14H,5H2

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 705939-58-8 4-[1-(4-methoxyphenyl)-3-trifluoro-methyl-1H-pyrazol-5-yl]phenol 
• 705939-60-2 C₁₆H₁₂F₃N₃O₂ 
• 1429940-08-8 (5R,7S)-5-(4-hydroxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid 4-fluoro-benzylamide 
• 1429939-74-1 C₂₄H₂₂F₄N₄O₃ 
• 1429939-73-0 C₂₄H₂₄F₄N₄O₃ 
• 1429940-04-4 (5R,7S)-5-(4-hydroxyphenyl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylic acid 
• 832136-43-3 C₁₆H₁₂F₃N₃O₃ 

Relevant academic research and scientific papers

Detection of amine vapors using luminescent xerogels from supramolecular metal-containing gelator

Supramolecular fluorescent gelators containing a tris(β- diketonato) complex are synthesized by using gelation-driving chelates, and their gelation abilities are studied with 15 solvents. Thin-layer films are prepared on quartz plates from the solutions and they are studied as chemosensors for amines. Fluorescence-quenching of the thin-layer films upon exposure to saturated primary and secondary amine vapors is monitored to evaluate the abilities of the chemosensors to detect amines. The morphologies of the thin-layer films are observed by transmission electron microscopy (TEM) and discussed in relation to their fluorescence-quenching. The fluorescence-quenching efficiencies upon exposure to saturated primary and secondary amines depend on the basicity and bulkiness of the amines rather than the vapor pressure. The fluorescence-quenching is caused by decomposition of a complex through nucleophilic addition of primary or secondary amines to its carbonyl group. The detection of tertiary amines is performed by monitoring the fluorescence emission from the thin-layer films, which are composed of a ligand and EuCl3. The emergence of fluorescence originates from the formation of fluorescent Eu3+-containing gelator, in which dehydrochloric acid by tertiary amines is a trigger for the complexation.

Discovery of tetrahydropyrazolopyrimidine carboxamide derivatives as potent and orally active antitubercular agents

Tetrahydropyrazolo[1,5-a]pyrimidine scaffold was identified as a hit series from a Mycobacterium tuberculosis (Mtb) whole cell high through-put screening (HTS) campaign. A series of derivatives of this class were synthesized to evaluate their structure-activity relationship (SAR) and structure-property relationship (SPR). Compound 9 had a promising in vivo DMPK profile in mouse and exhibited potent in vivo activity in a mouse efficacy model, achieving a reduction of 3.5 log CFU of Mtb after oral administration to infected mice once a day at 100 mg/kg for 28 days. Thus, compound 9 is a potential candidate for inclusion in combination therapies for both drug-sensitive and drug-resistant TB.

Pyrazole derivatives

A compound of the formula (I): wherein R1 is hydrogen or lower alkyl; R2 is lower alkyl, etc.; R3 is lower alkoxy, etc.; R4 is hydroxy, etc.; X is O, S, etc.; Y is CH or N; Z is lower alkylene or lower alkenylene; and m is 0 or 1; or salts thereof, which are useful as a medicament.

Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors

Several chemical modifications in the N1-benzenesulfonamide ring of celecoxib are presented. The series with a hydroxymethyl group adjacent to the sulfonamide was found to be the most potent modification that yielded many compounds selectively active against COX-2 enzyme in vitro.