57996-21-1

Basic information

• Product Name: 1(3H)-Isobenzofuranone, 7-methoxy-3-phenyl-
• CAS NO: 57996-21-1
• Molecular Formula: C15H12O3
• Molecular Weight: 240.258
• Mol File: 57996-21-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1(3H)-Isobenzofuranone, 7-methoxy-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1(3H)-Isobenzofuranone, 7-methoxy-3-phenyl-(57996-21-1)
• EPA Substance Registry System: 1(3H)-Isobenzofuranone, 7-methoxy-3-phenyl-(57996-21-1)

Safety Data

• Hazardous Substances Data: 57996-21-1(Hazardous Substances Data)

Upstream product

• 146014-66-6 methyl 2-fluoro-6-iodobenzoate 
• 111771-08-5 2-fluoro-6-iodobenzoic acid 
• 134172-65-9 m-methoxybenzhydrol 
• 14963-96-3 3-methoxyphthalic anhydride 
• 579-75-9 2-Methoxybenzoic acid 
• 100-52-7 benzaldehyde 
• 96597-77-2 3-Hydroxy-7-methoxy-3-phenyl-1(3H)-isobenzofuranon 
• 2886-59-1 1-methoxycyclohexa-1,4-diene 
• 72036-37-4 ethyl 4-hydroxy-4-phenylbut-2-ynoate 

Relevant articles and documents

Synthesis and antibacterial activity of racemic paecilocin A and its derivatives against methicillin-sensitive and -resistant Staphylococcus aureus

A total synthesis in four steps of racemic paecilocin A, a natural marine phthalide is reported. The synthetic pathway includes an iodine-magnesium exchange followed by a condensation on an aldehyde and represents a sufficiently flexible approach to allow the synthesis of twelve analogs. The synthesized compounds were investigated for their antibacterial activity against methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant strain (MRSA). Three analogs were found to have similar or better antibacterial activity than the natural compound on MRSA.

Directed ortho-metalation of unprotected benzoic acids. Methodology and regioselective synthesis of useful contiguously 3- and 6-substituted 2-methoxybenzoic acid building blocks

By treatment with s-BuLi/TMEDA at -78 °C, unprotected 2-methoxybenzoic acid is deprotonated exclusively in the position ortho to the carboxylate. A reversal of regioselectivity is observed when the acid is treated with n-BuLi/t-BuOK. These results are of general utility for the one-pot preparation of a variety of very simple 3- and 6-substituted 2-methoxybenzoic acids that are not easily accessible by conventional means. The potential usefulness of the method is demonstrated by the expedient synthesis of lunularic acid.

Synthesis of 3-Arylphthalides via Diels-Alder Reactions of Cyclohexa-1,3-dienes with Ethyl 4-Aryl-4-hydroxybut-2-ynoates

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