58022-21-2

Basic information

• Product Name: 1-ISOQUINOLIN-1-YL-ETHANONE
• Synonyms: 1-ISOQUINOLIN-1-YL-ETHANONE;Ethanone, 1-(1-isoquinolinyl)-;1-acetylisoquinoline;1-(Isoquinolin-1-yl)
• CAS NO: 58022-21-2
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.2
• Mol File: 58022-21-2.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 314.568 °C at 760 mmHg
• Flash Point: 152.033 °C
• Appearance: /
• Density: 1.154 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-ISOQUINOLIN-1-YL-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ISOQUINOLIN-1-YL-ETHANONE(58022-21-2)
• EPA Substance Registry System: 1-ISOQUINOLIN-1-YL-ETHANONE(58022-21-2)

Safety Data

• Hazardous Substances Data: 58022-21-2(Hazardous Substances Data)

Usage

General Description

1-ISOQUINOLIN-1-YL-ETHANONE is a chemical compound with the formula C11H9NO, and it belongs to the class of quinolinyl ketones. It is commonly used as an intermediate in the synthesis of various pharmaceuticals and organic compounds. This chemical has a wide range of applications in the pharmaceutical industry, as it can be used as a building block in the production of drugs and other bioactive molecules. Additionally, it has been studied for its potential pharmacological properties, such as antimicrobial and anti-inflammatory effects. Overall, 1-ISOQUINOLIN-1-YL-ETHANONE is a versatile compound with important implications in the field of medicine and organic chemistry.

InChI:InChI=1/C11H9NO/c1-8(13)11-10-5-3-2-4-9(10)6-7-12-11/h2-7H,1H3

Upstream product

• 119-65-3 isoquinoline 
• 75-07-0 acetaldehyde 
• 111-34-2 -butyl vinyl ether 
• 126921-72-0 1-acetylisoquinoline 2-oxide 
• 201230-82-2 carbon monoxide 
• 80-43-3 bis(1-methyl-1-phenylethyl)peroxide 
• 122-51-0 orthoformic acid triethyl ester 
• 127-17-3 2-oxo-propionic acid 
• 64-17-5 ethanol 
• 56-23-5 tetrachloromethane 
• 1198-30-7 1-isoquinolinecarbonitrile 
• 866328-99-6 N-methoxy-N-methylisoquinoline-1-carboxamide 
• 676-58-4 methylmagnesium chloride 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 86726-73-0 1-cinnamoylisoquinoline 
• 5467-83-4 1-[1]isoquinolyl-1-phenyl-ethanol 
• 1258282-77-7 methyl 1-acetylisoquinoline-4-carboxylate 
• 86726-74-1 1-hydroxy-3-phenyl-2-(1-phenylpyrrolo<2,1-a>isoquinolin-3-yl)-pyrrolo<2,1-a>isoquinoline 
• 86733-99-5 4-Nitro-benzoic acid 3-phenyl-pyrrolo[2,1-a]isoquinolin-1-yl ester 
• 87555-61-1 4-Phenyl-piperidine-1-carbothioic acid N'-(1-isoquinolin-1-yl-ethyl)-hydrazide 
• 87555-52-0 4-Phenyl-piperidine-1-carbothioic acid [1-isoquinolin-1-yl-eth-(Z)-ylidene]-hydrazide 
• 87555-53-1 C₁₉H₂₀N₄S 
• 87555-55-3 C₁₉H₂₆N₄S 
• 87555-46-2 C₁₉H₁₈N₄S 
• 87555-48-4 C₁₉H₂₄N₄S 
• 87555-66-6 methyl 3-<1-(1-isoquinolinyl)ethyl>hydrazinecarbodithioate 

Relevant articles and documents

Metal-, Photocatalyst-, and Light-Free Minisci C-H Acetylation of N-Heteroarenes with Vinyl Ethers

Herein, we report a mild, operationally simple method for Minisci C-H acetylation of N-heteroarenes using vinyl ethers as robust, inexpensive acetyl sources. The reactions do not require a conventional photocatalysis, electrocatalysis, metal catalysis, light activation, or high temperature. This method is thus significantly more sustainable than previously reported methods in terms of cost, reagent toxicity, and waste generation. This protocol can be expected to obtain medically relevant molecules from abundant feedstock materials.

Carbonylative Acetylation of Heterocycles

Herein, a new procedure for the carbonylative acetylation of heterocycles has been developed. In this process, organic peroxide acts as the methyl source. Various heterocycles were transformed into the corresponding methyl heterocyclic ketones in moderate to good yields.

Iron-catalyzed Minisci acylation of N-heteroarenes with α-keto acids

An efficient and mild protocol has been developed for the Minisci acylation reactions of nitrogen-containing heteroarenes with α-keto acids. Distinct from the conventional Minisci acylation conditions, the chemistry was performed using non-noble metal Fe(II), instead of expensive Ag(I) salt, as catalyst. A wide range of substrates, including aliphatic or aromatic α-keto acids, as well as various N-heteroarenes, proved to be compatible with the protocol. Scale-up experiment also demonstrates the practicality of the approach.