58035-57-7Relevant academic research and scientific papers
Bimacrocyclic Pyridines and 1,8-Naphthyridines: Basicities and Application in Base Catalysis 1
Liebig, Timo,Lüning, Ulrich
, p. 2799 - 2807 (2014)
Di-α-substituted N-heterocycles such as 2,6-halogenopyridines or 2,7-dichloro-1,8-naphthyridines can be coupled with 2,6-bis(alkenyloxy) substituted areneboronic acids. The resulting tetraenes are then cyclized by ring-closing metathesis to give bimacrocyclic concave pyridines or concave 1,8-naphthyridines. The relative basicity of the concave N-heterocycles was measured and their activity and selectivity was tested in the base-catalyzed addition of alcohols to diphenylketene.
