58038-50-9

Upstream product

• 95-16-9 1,3-Benzothiazole 
• 127-19-5 N,N-dimethyl acetamide 
• 2516-40-7 2-bromo-1,3-benzothiazole 
• 7144-49-2 2-methanesulfonylbenzothiazole 
• 64345-00-2 2-(phenylsulfonyl)benzo[d]thiazole 
• 615-20-3 2-chlorobenzo[d][1,3]thiazole 

Relevant academic research and scientific papers

Amidoalkylation of Sulfonylheteroarenes with Alkylamides through a Radical Chain Mechanism

In the presence of a substoichiometric amount of a tert-butoxy radical precursor and a base, alkylamides were found to be heteroarylated at their α-C?H bonds with sulfonylheteroarenes through homolytic aromatic substitution, where a radical chain is operative.

Photocatalytic (Het)arylation of C(sp3)-H Bonds with Carbon Nitride

Graphitic carbon nitride materials have attracted significant interest in recent years and found applications in diverse light-to-energy conversions such as artificial photosynthesis, CO2 reduction, or degradation of organic pollutants. However, their utilization in synthetic photocatalysis, especially in the direct functionalization of C(sp3)-H bonds, remains underexplored. Herein, we report mesoporous graphitic carbon nitride (mpg-CN) as a heterogeneous organic semiconductor photocatalyst for direct arylation of C(sp3)-H bonds in combination with nickel catalysis. Our protocol has a broad synthetic scope (>70 examples including late-stage functionalization of drugs and agrochemicals), is operationally simple, and shows high chemo- and regioselectivities. Facile separation and recycling of the mpg-CN catalyst in combination with its low preparation cost, innate photochemical stability, and low toxicity are beneficial features overcoming typical shortcomings of homogeneous photocatalysis. Detailed mechanistic investigations and kinetic studies indicate that an unprecedented energy-transfer process (EnT) from the organic semiconductor to the nickel complex is operating.

Alkylation reactions of benzothiazoles with N,N-dimethylamides catalyzed by the two-component system under visible light

Eosin Y/K2S2O8 catalyzed C2-alkylation reactions of benzothiazoles with N,N-dimethylamides under visible light have been developed. The reactions completed smoothly in the presence of Eosin Y as the photocatalyst and Ksub

Application of a substituted benzothiazole C2 amide alkylation derivative as a fungicide

The invention discloses application of a substituted benzothiazole C2 amide alkylation derivative as a fungicide. The structure of the derivative is shown as a formula (I). In the formula (I), a substitute R1 is hydrogen or C1-C5 alkyl; H on a benzothiazole ring is monosubstituted, polysubstituted or unsubstituted by a substituent R, with the C2 site of the benzothiazole ring is not substituted bythe R; n is an integer of 0 to 4, and represents the number of the substituents R on the benzothiazole ring; when the n is 0, indicating that H on the benzothiazole ring is not substituted; when then is 1, indicating that the H on the benzothiazole ring is monosubstituted by the substituent R; when the n is 2 to 4, indicating that H on the benzothiazole ring is polysubstituted by the substituents R, with the substituents R at different substation positions being same or different; the substituent R is hydrogen, C1-C5 alkyl, C1-C2 alkoxyaryl, or halogen. The derivative has good inhibitory effects on fungi causing wheat scab, corn southern leaf blight, cucumber anthracnose and rice sheath blight disease.

Preparation method of substituted benzothiazole C2 alkylation derivative

The invention discloses a preparation method of a substituted benzothiazole C2 alkylation derivative. The preparation method comprises the following steps: carrying out a stirring reaction at room temperature in a solvent by using substituted benzothiazole and an N,N-dimethylamide compound as raw materials in the presence of a photosensitizer and an oxidant with an LED (Light Emitting Diode) whitelight lamp as a light source; performing TLC (Thin-Layer Chromatography) monitoring until the end of the reaction; separating and purifying the obtained reaction solution to prepare the substituted benzothiazole C2 alkylation derivative. A novel method for synthesizing the benzothiazole C2 alkylation derivative from benzothiazole and dimethylamide as raw materials with a cheap and readily-available organic dye as a photosensitizer and K2S2O8 as an oxidant through visible light induction at room temperature is provided. The method has the advantages of mild reaction conditions, cheap and readily-available catalyst and high yield. Moreover, a synthesis method of alkali catalysis or transition metal catalysis common for benzothiazole alkylation is omitted, the cost is greatly lowered, the economic efficiency is improved, and the development of enterprises in market competition is facilitated.

Transition Metal-Free Amidoalkylation of Benzothiazoles and Amidoalkylarylation of Activated Alkenes with N,N-Dialkylamides

A general and practical amidoalkylation reaction, using N,N-dialkylamides in the presence of potassium persulfate as the sole reagent, has been developed. 2-Amidoalkylated benzothiazole- and 3-amidoalkyl-substituted indolinone derivatives were obtained by