58045-41-3Relevant academic research and scientific papers
Palladium(II) complexes of (t-butyl salicylidene) diphenyl disulfide diamine: synthesis, structure, spectral characterization and catalytic properties
Bhowon, Minu G.,Jhaumeer Laulloo, Sabina,Hosten, Eric C.,Elaheebacus, Sumayya,Dowlut, Mounisha R.
, p. 537 - 545 (2021)
The hexadentate N2S2O2 donor ligand N,N’-bis(3,5-tert-butylsalicylidene) diphenyl disulfide-2,2’-diamine was synthesised by the condensation of 2-aminophenyl disulfide and 3,5-di-tert-butyl-2-hydroxybenzaldehyde and its mo
Topochemical Photopolymerization of 4-cinnamates and -thiocinnamates in the Crystalline State
Saigo, Kazuhiko,Sukegawa, Makoto,Maekawa, Yasunari,Hasegawa, Masaki
, p. 2355 - 2362 (1995)
Topochemical photopolymerization of 4--cinnamates and -thiocinnamates were carried out in the crystalline state.Upon photoirradiation, ethyl 4-cinnamates and S-ethyl 4-thiocynnamates gave α-hetero-type crystallinem linear polymers, whereas methyl 4-cinnamates afforded mixtures of β-type oligomers.The X-ray crystallographic analyses of the monomers revealed that the thioesters were more favorable monomers that the corresponding esters from the viewpoint of close packing in a crystal.The following factor(s) would play an important role in determining their molecular arrangements: 1) The close contact between the central 1,4-phenylene ring and the alkoxy oxygen of the ester group or the alkylthio sulfur of the thioester group, 2) the hydrogen bond between the interstacked pyrazinyl groups, and/or 3) the gearing of the alkyl group in the ester moiety with the methylpyrazinyl group.
Removal of soluble palladium complexes from reaction mixtures by fixed-bed adsorption
Girgis, Michael J.,Kuczynski, Laura E.,Berberena, Sonia M.,Boyd, Caitlin A.,Kubinski, Pamela L.,Scherhob, Megerle L.,Drinkwater, Donald E.,Shen, Xiaoxuan,Babiak, Stanislaw,Lefebvre, Brian G.
, p. 1209 - 1217 (2008)
The increasing use of metal-containing catalysts in producing pharmaceutical intermediates and active pharmaceutical ingredients, in conjunction with requirements of low metal content in a drug substance, has motivated the development of efficient separations processes for metals removal. In this paper, fixed-bed adsorption, an attractive alternative to batch adsorption, was investigated using a reaction mixture from a Heck coupling. Adsorption isotherm determinations using three candidate adsorbents revealed that QuadraPure TU had the greatest affinity and identified the optimal adsorption temperature. The bed residence time was key in obtaining good adsorption efficiency in subsequent fixed-bed experiments. Methods for palladium detection by HPLC were developed to monitor adsorption column performance in quasi real-time. A preliminary design methodology was developed in which actual breakthrough time is estimated from the experimentally determined tradeoff between bed efficiency and residence time. Even at the realized 55% bed efficiency, fixed-bed adsorption requires less than one-fourth the adsorbent needed for a single-stage batch adsorption process.
HISTONE DEACETYLASE 6 INHIBITORS AND METHOD FOR TREATING NEUROPATHIC PAIN
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Paragraph 0068; 0082-0083, (2021/01/29)
Disclosed herein are hydroxamic acid compounds. Also disclosed is a method of using the hydroxamic acid compounds for treating a condition associated with histone deacetylase 6.
Triazine-hyperbranched polymer-modified magnetic nanoparticles-supported nano-cobalt for C–C cross-coupling reactions
Hajipour, Abdol R.,Sadeghi, Shaghayegh
, p. 3219 - 3233 (2021/08/06)
Design of hyperbranched polymers (HBPs) and crafting them in catalytic systems especially in organic chemistry are a relatively unexplored domain. This paper reports the utilization of triazine-hyperbranched polymer (THBP)-coated magnetic chitosan nanoparticles (MCs) as stabilizing matrix for cobalt nanoparticles. Cobalt nanoparticles were fabricated by coordination cobalt(II) ions with amine-terminated triazine polymer and then reduced into Co(0) using sodium borohydride in aqueous medium. The Co(0)-THBP@MCs were fully characterized by FT-IR, SEM–EDX, TEM, and TGA analyses. The presence of metallic cobalt was determined by ICP and XRD techniques. This novel hyperbranched polyaromatic polymer-encapsulated cobalt nanoparticles showed high catalytic activity in Mizoroki–Heck and Suzuki–Miyaura cross-coupling reactions. Heck and Suzuki reactions were carried out using 0.35 and 0.4?mol% of cobalt nanoparticles in which the turnover number (TON) values were calculated as 271 and 225, respectively. In addition, the produced heterogeneous catalyst could be recovered and reused without considerable loss of activity. Oxygen stability and high reusability over 7 runs with trace leaching of the cobalt into the reaction media as well as moisture stability of the immobilized cobalt nanoparticles are their considerable worthwhile advantages.
Pd salen complex@CPGO as a convenient, effective heterogeneous catalyst for Suzuki–Miyaura and Heck–Mizoroki cross-coupling reactions
Ghabdian, Mahdieh,Nasseri, Mohammad Ali,Allahresani, Ali,Motavallizadehkakhky, Alireza
, p. 1713 - 1728 (2018/05/25)
A Pd(II) Schiff base complex supported on graphene oxide nanosheets (Pd(II) salen@CPGO) has been synthesized and characterized by FT-IR, ICP-AES, XRD, SEM/EDX and TEM. The synthesized nanocatalyst has been found to be an efficient heterogeneous catalyst for Suzuki–Miyaura and Heck–Mizoroki coupling reactions. Pd(II) salen@CPGO could be separated and recovered easily from the reaction mixture and recycled several times without a discernible decrease in its catalytic activity. The construction of a solid sheet-supported Pd catalyst would be expected to be a promising system to perform heterogeneous catalytic reactions.
Curcumin histone deacetylase inhibitor and preparation method and medical application thereof
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Paragraph 0038-0041, (2021/07/24)
The invention relates to the fields of medicinal chemistry and biology, in particular to a curcumin histone deacetylase inhibitor. The invention also discloses a preparation method of the inhibitor and an application of the inhibitor in exerting anti-tumor activity by inhibiting histone deacetylase.
Synthesis and structural characterization of a palladium complex as an anticancer agent, and a highly efficient and reusable catalyst for the Heck coupling reaction under ultrasound irradiation: A convenient sustainable green protocol
El-bendary, Mohamed M.,Saleh, Tamer S.,Al-Bogami, Abdullah S.
, (2020/12/02)
The complex [Pd(paOH)2].2Cl (1) was synthesized by the self-assembly method with palladium chloride and pyridine-2-carbaldehyde-oxime (paOH) in aqueous acetonitrile solution under ambient conditions. Complex 1 was fully characterized by FT-IR, UV–vis and NMR spectroscopic techniques, as well as elemental analysis. The single crystal X-ray structure of complex 1 indicates that the Pd(II) ion is bonded to four nitrogen atoms from two pyridine-2-carbaldehyde-oxime ligands. The molecular geometry of the Pd(II) ion in complex 1 is distorted square-planar with a trans geometry and with two free chloride ions. Using an MTT assay, the anticancer activities of the palladium complex 1 were studied with respect to human breast cancer (MCF-7) and hepatocellular carcinoma (HePG-2) cell lines. The data obtained show that complex 1 displays strong activity towards the viability and the growth of the cancer cell lines MCF-7 and HepG2. Additionally, complex 1 exhibits excellent catalytic activity for the Heck cross-coupling reaction with water as the solvent under ultrasound irradiation. Ultrasound irradiation not only enhanced the rate and the yield of the reaction, but also promoted the in situ generation of a well-dispersed zero-valent Pd-colloidal species as the active catalyst from complex 1. Finally, the luminescence spectrum of complex 1 is discussed.
Development and pre-clinical testing of a novel hypoxia-activated KDAC inhibitor
Skwarska, Anna,Calder, Ewen D.D.,Sneddon, Deborah,Bolland, Hannah,Odyniec, Maria L.,Mistry, Ishna N.,Martin, Jennifer,Folkes, Lisa K.,Conway, Stuart J.,Hammond, Ester M.
, p. 1258 - 13,1270 (2021/09/16)
Tumor hypoxia is associated with therapy resistance and poor patient prognosis. Hypoxia-activated prodrugs, designed to selectively target hypoxic cells while sparing normal tissue, represent a promising treatment strategy. We report the pre-clinical efficacy of 1-methyl-2-nitroimidazole panobinostat (NI-Pano, CH-03), a novel bioreductive version of the clinically used lysine deacetylase inhibitor, panobinostat. NI-Pano was stable in normoxic (21% O2) conditions and underwent NADPH-CYP-mediated enzymatic bioreduction to release panobinostat in hypoxia (2). Treatment of cells grown in both 2D and 3D with NI-Pano increased acetylation of histone H3 at lysine 9, induced apoptosis, and decreased clonogenic survival. Importantly, NI-Pano exhibited growth delay effects as a single agent in tumor xenografts. Pharmacokinetic analysis confirmed the presence of sub-micromolar concentrations of panobinostat in hypoxic mouse xenografts, but not in circulating plasma or kidneys. Together, our pre-clinical results provide a strong mechanistic rationale for the clinical development of NI-Pano for selective targeting of hypoxic tumors.
Coordination from Heteroscorpionate Ligand Towards Pd(II) via Pd???Hδ?C(sp3) Interaction: Structural and Catalytic Studies
Castillo-Moreno, Miguel ángel,Cruz-Borbolla, Julián,González-Montiel, Simplicio,Ignacio Sandoval-Chávez, César,Manuel Vásquez-Pérez, José,Mendoza-Espinosa, Daniel,Salazar-Pereda, Verónica
supporting information, p. 2661 - 2668 (2021/07/06)
The coordination ability of the heteroscorpionate ligand 2,2-bis(3,5-dimethylpyrazol-1-yl)-1-p-tolylethanol (1) towards palladium (II) dihalides was evaluated. The structures of the respective palladium complexes (2 and 3) were elucidated in solution by NMR spectroscopy, and their molecular structures were established by single crystal X-ray diffraction analyses. Both studies revealed the existence of Pd???Hδ?C(sp3) anagostic interactions. The molecular structure of complexes 2 and 3 displays coordination of ligand 1 to palladium in a κ3-NNH tridentate fashion via two nitrogen atoms and one δ-anagostic H???Pd interaction. The metal center exhibits a square pyramidal geometry. The distances of anagostic Hδ???Pd interactions ranged from 2.566 to 2.576 ?. The δ-anagostic H???Pd interactions in complexes 2 and 3 were also identified by Bader's quantum theory of atoms in molecules (QTAIM) and non-covalent interaction (NCI) analysis. The catalytic efficiencies of complexes 2 and 3 in the Suzuki-Miyaura cross-coupling reactions were evaluated and the results showed that palladium (II) dibromide complex is the most efficient of the series. Complex 3 was also evaluated in Mizoroki-Heck cross-coupling reactions.
