58054-88-9Relevant academic research and scientific papers
Development of an Enantioselective [3 + 2] Cycloaddition to Synthesize the Pyrrolidine Core of ABBV-3221 on Multikilogram Scale
Hartung, John,Greszler, Stephen N.,Klix, Russell C.,Kallemeyn, Jeffrey M.
, p. 2532 - 2537 (2019)
The tetrasubstituted pyrrolidine core of ABBV-3221 was synthesized by catalytic, enantioselective cycloaddition. A Cu(I) catalyst system was identified as ideal for further development, which gave a 78% yield of 99% purity product after optimization. The
