58061-82-8

Upstream product

• 109-79-5 n-butanethiol 
• 62-53-3 aniline 
• 100-00-5 4-chlorobenzonitrile 
• 540-37-4 p-aminoiodobenzene 
• 629-45-8 dibutyl disulfide 

Downstream Products

• 105041-54-1 4-butylsulfanyl-benzoyl chloride 
• 22683-49-4 4-butylthio benzoic acid 
• 94966-88-8 N,N'-bis-(4-butylsulfanyl-phenyl)-thiourea 
• 27978-32-1 chloro-acetic acid-(4-butylsulfanyl-anilide) 
• 219915-65-8 n-butyl(4-cyanophenyl)sulfide 

Relevant academic research and scientific papers

Benzothiazole carbamates and amides as antiproliferative species

A series of new benzothiazole-based carbamates and amides were synthesized and their antiproliferative activity was determined. Derivatives with profound activity were identified and further investigated for their possible mechanism of action. It was found that these compounds induce specific apoptosis, G2/M cell cycle arrest and decrease ROS level in MCF-7 human breast cancer cell line. Moreover, submicromolar antiproliferative activity of examined carbamates against NT2/D1 testicular embryonal carcinoma was shown. The most potent derivatives strongly inhibited NT2/D1 cell migration and invasiveness.

Metal-Free Iodine-Catalyzed Direct Arylthiation of Substituted Anilines with Thiols

Iodine-catalyzed direct arylthiation of substituted anilines for the synthesis of various diaryl sulfides has been developed under metal- and solvent-free conditions. The present method uses readily available thiols as the arylthiation reagents, and envir

Cu-catalyzed coupling of aryl iodides with thiols using carbonyl-phosphine oxide ligands

A series of carbonyl-phosphine oxide ligands were synthesized from 2-bromophenylaldehyde and used in Cu-catalyzed C-S coupling reactions. Aryl iodide and aryl bromide reacted with thiols efficiently upon catalysis under mild reaction conditions and a yiel

Cu-Catalyzed Coupling of Aryl Iodides with Thiols Using Carbonyl-Phosphine Oxide Ligands

A series of carbonyl-phosphine oxide ligands were synthesized from 2-bromophenylaldehyde and used in Cu-catalyzed C-S coupling reactions. Aryl iodide and aryl bromide reacted with thiols efficiently upon catalysis under mild reaction conditions and a yiel

One-pot synthesis of amine-substituted aryl sulfides and benzo[ b ]thiophene derivatives

A series of amine-substituted aryl sulfides have been synthesized from nitroaryl halides via a simple one-pot procedure involving metal-free C-S cross-coupling and in situ nitro group reduction. Various nitroaryl halides were reacted with thiols in recyclable poly(ethylene glycol) to afford the amine-substituted aryl sulfides in high yield. Additionally, the cross-coupling reactions of nitro- and aldehyde-substituted aryl halides with benzyl thiols under the same reaction conditions were demonstrated to afford benzothiazole and phenylbenzo[b]thiophene derivatives.

L-proline-promoted CuI-catalyzed C-S bond formation between aryl iodides and thiols

An improved, mild procedure for the CuI-catalyzed coupling reactions of aryl iodides with aliphatic and aromatic thiols, using L-proline as the ligand, is reported. This procedure is noteworthy given its high generality and exceptional level of functional group toleration. Copyright Taylor & Francis Group, LLC.

Alkyl- or arylthiolation of aryl iodide via cleavage of the S-S bond of disulfide compound by nickel catalyst and zinc

Various aryl sulfides can be synthesized by nickel-catalyzed alkyl- or arylthiolation of aryl iodide with a disulfide compound. This reaction produces Ni(0) from NiBr2-bpy by the reduction with zinc, and this generated complex works as an activating species to convert ArI into ArSR under neutral conditions. Furthermore, this system enables the use of two RS groups in (RS)2.