58096-07-4Relevant academic research and scientific papers
Efficient synthetic route toward biologically active γ-carboline derivatives
Hingane, Dattatray G.,Parekh, Nikita P.,Khan, Ayesha,Kusurkar, Radhika S.
, p. 160 - 164 (2016/02/23)
An efficient and short route was established for the synthesis of anti-bovine viral diarrhea virus agents, namely 4-methyl-γ-carboline (SK4M) 1, 3-methyl-γ-carboline (SK3M) 2, 5-methyl-γ-carboline (SK5M) 3, and a new γ-carboline derivative 4, using therma
γ-Carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity
Sako, Kumiko,Aoyama, Hiroshi,Sato, Shinichi,Hashimoto, Yuichi,Baba, Masanori
, p. 3780 - 3790 (2008/12/20)
Based on anti-viral screening of our heteroaromatics derived from thalidomide, the γ-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-γ-carboline), with the EC50 of 0.26 μM.
Synthesis and DNA binding properties of γ-carbolinium derivatives and benzologues
Molina,Vaquero,Garcia-Navio,Alvarez-Builla,De Pascual-Teresa,Gago,Rodrigo,Ballesteros
, p. 5587 - 5599 (2007/10/03)
The 5H-pyrido[4,3-b]indole, 11H-indolo[3,2-c]quinoline, 5H-benzo[f]pyrido[4,3-b]indole, and 13H-benz[5,6]indolo[3,2-c]quinoline heteroaromatic nuclei have been synthesized by the Graebe-Ullmann method by classical heating or under microwave irradiation. These tri-, tetra-, and pentacyclic compounds were transformed into the corresponding cationic derivatives by N-alkylation, and the DNA-binding properties of the resulting cationic systems were examined using UV-vis spectroscopy, viscometric determinations, and molecular modeling techniques. The tetracyclic cations were transformed into bis-salts by means of a diethyl bispiperidine rigid chain and a more flexible polyamide linker, but the low solubility of these bis-salts made the study of their bisintercalating properties difficult.
