581-01-1

Upstream product

• 100-52-7 benzaldehyde 
• 151-50-8 potassium cyanide 

Downstream Products

• 394-05-8 4-(4-fluoro-phenyl)-4-oxo-2-phenyl-butyric acid methyl ester 
• 116776-66-0 4-[6-(4-Fluoro-phenyl)-4-phenyl-pyridazin-3-yl]-morpholine 
• 116776-69-3 6-(4-Fluoro-phenyl)-4-phenyl-3-piperidin-1-yl-pyridazine 
• 116776-57-9 6-(4-Fluoro-phenyl)-2-methyl-4-phenyl-4,5-dihydro-2H-pyridazin-3-one 
• 116776-54-6 6-(4-Fluoro-phenyl)-4-phenyl-4,5-dihydro-2H-pyridazin-3-one 
• 116776-59-1 6-(4-Fluoro-phenyl)-4-phenyl-2H-pyridazin-3-one 
• 116776-61-5 3-Chloro-6-(4-fluoro-phenyl)-4-phenyl-pyridazine 
• 394-08-1 4-(4-fluoro-phenyl)-4-oxo-2-phenyl-butyric acid 

Relevant academic research and scientific papers

Cyano-borrowing reaction: Nickel-catalyzed direct conversion of cyanohydrins and aldehydes/ketones to β-cyano ketone

A direct nickel-catalyzed, high atom- and step-economical reaction of cyanohydrins with aldehydes or ketones via an unprecedented "cyano-borrowing reaction" has been developed. Cleavage of the C-CN bond of cyanohydrins followed by aldol condensation and conjugate addition of cyanide to α,β-unsaturated ketones proceeded to deliver a range of racemic β-cyano ketones with good to high yields. The practical procedure with the use of a commercial and less-toxic CN source bodes well for wide application of this protocol.