581072-15-3Relevant academic research and scientific papers
BENZISOXAZOLE COMPOUND
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Paragraph 0207-0208, (2021/03/13)
The present invention provides a compound, a salt thereof, or a prodrug thereof as a compound effective for preventing and/or treating fibrosis, the compound being represented by formula (1) (wherein A is an optionally substituted benzene ring; B is optionally substituted aryl or optionally substituted heteroaryl; X is an oxygen atom or a sulfur atom; Y is a nitrogen atom or a carbon atom; ------ of -----Y is a single or double bond when Y is a carbon atom, or ------ of -----Y is a single bond when Y is a nitrogen atom; each R1 independently represents lower alkyl, or two R1s may be bound to each other to form a spiro ring or a crosslinked structure, or two R1s may be bound to each other to form a saturated fused heterocycle together with nitrogen and carbon atoms constituting a ring containing Y; p is 0, 1, or 2; or (R1)p is oxo) .
PROCESSES TO PRODUCE ELAGOLIX
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Page/Page column 10; 11, (2019/06/23)
The present invention relates to a scalable process for the making of elagolix, its salts and the process of intermediate compounds.
[...] and its sodium salt intermediate and its salt preparation method and application (by machine translation)
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Paragraph 0033-0035, (2019/05/06)
The invention application [...] and its sodium salt intermediate and its salt preparation method and application, relates to medical intermediate and its preparation method and application. The present invention provides a process content provided by the
Synthesis method of key raw material compound C of Elagolix
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Paragraph 0043-0047; 0055-0056; 0062-0063, (2018/06/15)
The invention relates to a synthesis method of a key raw material compound C of Elagolix. The synthesis method comprises the following steps: performing reaction of 3-flourine-trifluorotoluene, an organic lithium reagent and DMF in the presence of TMEDA a
Oxime Carbamate-Discovery of a series of novel FAAH inhibitors
Sit,Conway, Charles M.,Xie, Kai,Bertekap, Robert,Bourin, Clotilde,Burris, Kevin D.
supporting information; experimental part, p. 1272 - 1277 (2010/06/17)
A series of novel oxime carbamates have been identified as potent inhibitors of the key regulatory enzyme of the endocannabinoid signaling system, fatty acid amide hydrolase (FAAH). In this Letter, the rationale behind the discovery and the biological evaluations of this novel class of FAAH inhibitors are presented. Both in vitro and in vivo results of selected targets are discussed, along with inhibition kinetics and molecular modeling studies.1.
AZABICYCLONONENE DERIVATIVES AS RENIN INHIBITORS
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Page/Page column 33, (2010/11/08)
The invention relates to novel bicyclononene derivatives, related compounds and use thereof as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the
