581076-64-4 Usage
Uses
Used in Pharmaceutical Production:
2-(5-amino-2-methylphenyl)guanidine is used as an intermediate in the synthesis of various pharmaceuticals due to its unique chemical structure and reactivity, contributing to the development of new medications.
Used in Organic Synthesis:
As a reagent in organic synthesis, 2-(5-amino-2-methylphenyl)guanidine is utilized for its ability to participate in a range of chemical reactions, facilitating the creation of diverse organic compounds.
Used in Neurological Disorder Treatment:
2-(5-amino-2-methylphenyl)guanidine is studied for its potential as a therapeutic agent in the treatment of neurological disorders, leveraging its biochemical properties to address specific conditions.
Used as an Anticonvulsant:
2-(5-amino-2-methylphenyl)guanidine is explored for its anticonvulsant properties, indicating its potential use in managing conditions characterized by seizures or abnormal electrical activity in the brain.
Used in Antibacterial and Antifungal Research:
2-(5-amino-2-methylphenyl)guanidine's possible antibacterial and antifungal properties make it a valuable subject of research for the development of new antimicrobial agents to combat resistant strains and infections.
Used in Drug Development:
Its multifaceted potential applications position 2-(5-amino-2-methylphenyl)guanidine as a significant compound in the realm of drug development, where it may lead to the creation of innovative treatments for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 581076-64-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,8,1,0,7 and 6 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 581076-64:
(8*5)+(7*8)+(6*1)+(5*0)+(4*7)+(3*6)+(2*6)+(1*4)=164
164 % 10 = 4
So 581076-64-4 is a valid CAS Registry Number.
581076-64-4Relevant academic research and scientific papers
Urea derivatives of STI571 as inhibitors of Bcr-Abl and PDGFR kinases
Manley, Paul W.,Breitenstein, Werner,Brüggen, Josef,Cowan-Jacob, Sandra W.,Furet, Pascal,Mestan, Jürgen,Meyer, Thomas
, p. 5793 - 5797 (2007/10/03)
Urea-based analogues of STI571 are described possessing structural features which can differentiate between Abl/Bcr-Abl and PDGFR kinase inhibition. The constitutively active Abl kinase activity of the Bcr-Abl oncoprotein is causative for chronic myelogenous leukemia. Urea derivatives, structurally related to the therapeutic agent STI571, have been identified, which potently inhibit the tyrosine kinase activity of recombinant Abl. In particular a dimethylamino-aniline derivative (18) inhibited c-Abl transphosphorylation with an IC50 value of 56 nM. Although this activity was not translated into cellular activity against the constitutively activated oncogenic Bcr-Abl, a number of compounds from this series potently inhibited cellular PDGFR autophosphorylation. It was also possible to differentiate between c-Abl and PDGFR kinase inhibition, with compound 22 being selective towards Abl and 23 selective for PDGFR.
2-AMINOPYRIMIDINE DERIVATIVES AS RAF KINASE INHIBITORS
-
, (2010/02/09)
This application discloses compounds that inhibit Raf kinase having the formula (I), wherein R1 is a phenyl radical or a heteroaryl radical; and R2 is a phenyl radical; or an N-oxide or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of proliferative diseases, such as cancer.
