581098-29-5

Upstream product

• 3678-62-4 2-chloro-4-picoline 
• 116332-54-8 4-fluoro-N-methoxy-N-methylbenzamide 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 158876-69-8 2-(2-chloropyridin-4-yl)-1-(4-fluorophenyl)ethanone 

Downstream Products

• 581098-57-9 4-[2-benzylsulfanyl-5-(4-fluorophenyl)-3H-imidazol-4-yl]-2-chloropyridine 
• 581098-43-3 2-chloro-4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)pyridine 
• 581098-66-0 4-(4-fluorophenyl)-5-[2-(1-phenylethylamino)pyridin-4-yl]-1,3-dihydro-imidazole-2-thione 
• 581098-41-1 4-(2-chloropyridin-4-yl)-5-(4-fluorophenyl)-1,3-dihydroimidazole-2-thione 

Relevant academic research and scientific papers

A concise and optimized four-step approach toward 2-(aryl-)alkylsulfanyl-, 4(5)-aryl-, 5(4)-heteroaryl-substituted imidazoles using alkyl- or arylalkyl thiocyanates

A convenient cyclization method leading to trisubstituted imidazoles in up to 84% yield is reported. Diverse 1-aryl-, 2-heteroaryl-substituted ethanones are converted into the corresponding α-oximino derivatives which are reduced under regioselective cond

2-THIO-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE IN PHARMACEUTICS

The invention relates to 2-thio-substituted imidazole derivatives of formula (I), wherein the radicals R1, R2, R3 and m have the meanings as cited in the description. The inventive compounds comprise an immunomodulatory action and/or an action that inhibits the release of cytokines and are thus suited for treating diseases associated with a disorder of the immune system.

Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes

A series of polysubstituted pyridin-4-yl imidazole inhibitors of p38 MAP (mitogen-activated protein) kinase was prepared as small molecular anticytokine agents and drug candidates for the treatment of chronic inflammatory diseases. The contribution of sub