581098-66-0

Upstream product

• 618-36-0 rac-methylbenzylamine 
• 581098-57-9 4-[2-benzylsulfanyl-5-(4-fluorophenyl)-3H-imidazol-4-yl]-2-chloropyridine 
• 3678-62-4 2-chloro-4-picoline 
• 333-20-0 potassium thioacyanate 
• 581098-41-1 4-(2-chloropyridin-4-yl)-5-(4-fluorophenyl)-1,3-dihydroimidazole-2-thione 
• 581098-29-5 1-(2-chloropyridin-4-yl)-2-(4-fluorophenyl)ethane-1,2-dione 1-oxime 
• 158876-69-8 2-(2-chloropyridin-4-yl)-1-(4-fluorophenyl)ethanone 
• 116332-54-8 4-fluoro-N-methoxy-N-methylbenzamide 

Downstream Products

• 1012305-75-7 diethyl (4-(4-fluorophenyl)-5-(2-(1-phenylethylamino)pyridin-4-yl)-1H-imidazol-2-ylthio)methylphosphonate 
• 1012305-60-0 3-((4-(4-fluorophenyl)-5-(2-((1-phenylethyl)amino)pyridin-4-yl)-1Himidazol-2-yl)thio)propane-1,2-diol 
• 1061601-89-5 methyl 2-(4-(4-fluorophenyl)-5-(2-(1-phenylethylamino)pyridin-4-yl)-1H-imidazol-2-ylthio)acetate 
• 1012305-74-6 2-(4-(4-fluorophenyl)-5-(2-(1-phenylethylamino)pyridin-4-yl)-1H-imidazol-2-ylthio)acetic acid 

Relevant academic research and scientific papers

2-SULFANYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS

The invention relates to 2-thio-substituted imidazole derivatives of the Formula I, and to methods of use thereof.

Towards the improvement of the synthesis of novel 4(5)-aryl-5(4)- heteroaryl-2-thio-substituted imidazoles and their p38 MAP kinase inhibitory activity

A series of 2-alkylsulfanyl-4-(4-fluorophenyl)-5-(2-aminopyridin-4-yl)- substituted imidazoles was prepared and interaction possibilities of the 2-thioether moiety with phosphate/ribose binding pockets of p38 MAP kinase were investigated. Introduction of the alkyl/benzyl amino function at the pyridine moiety was carried out via nucleophilic substitution or via palladium catalyzed aryl-C-N-bond formation. The Royal Society of Chemistry 2008.

Targeting the ribose and phosphate binding site of p38 mitogen-activated protein (MAP) kinase: Synthesis and biological testing of 2-alkylsulfanyl-, 4(5)-aryl-, 5(4)-heteroaryl-substituted imidazoles

Three series of substituted 2-alkylsulfanyl-4-(4-fluorophenyl)imidazoles, 5-pyridinyl-, 1-methyl-5-pyridinyl-, and 5-(2-aminopyridin-4-yl)-imidazoles, were prepared and tested for their ability to inhibit p38 MAP kinase and TNF-α release. These compounds

Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes

A series of polysubstituted pyridin-4-yl imidazole inhibitors of p38 MAP (mitogen-activated protein) kinase was prepared as small molecular anticytokine agents and drug candidates for the treatment of chronic inflammatory diseases. The contribution of sub