5816-96-6

Upstream product

• 1007476-32-5 sodium ethyl acetylacetate enolate 
• 103-72-0 phenyl isothiocyanate 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 408531-04-4 3-anilino-2H-isoxazol-5-one 
• 18629-86-2 2-acetyl-N-phenyl-malonamic acid ethyl ester 
• 10374-68-2 ethyl 2-phenylthiocarbamoyl acetate 
• 87646-40-0 2-antipyrinylhydrazonothioacetoacetanilide 
• 120-75-2 2-Methylbenzothiazole 
• 1346240-76-3 5-anilino-4-antipyrinylazo-2-ethoxycarbonyl-3-hydroxythiophene 
• 1346240-75-2 5-anilino-4-antipyrinylazo-2-benzoyl-3-hydroxythiophene 
• 1233399-13-7 2-acetyl-5-anilino-4-antipyrinylazo-3-hydroxythiophene 
• 1346240-73-0 ethyl 2-antipyrinylhydrazono-2-phenylthiocarbamoylacetate 
• 637-53-6 thioacetanilide 
• 87633-20-3 4-Anilino-3-methyl-1,5-benzodiazepin-3-one-3-(4-antipyrinylhydrazone) 
• 87633-19-0 6-Anilino-2,5-dihydro-4-methyl-2-thionopyrimidine-5-one-5-(antipyrinylhydrazone) 

Relevant academic research and scientific papers

Spectral, magnetic, thermal and electro-chemical studies on ethyl-α-(N- phenylthiocarbamyl)acetoacetate complexes

Complexes of ethyl-α-(N-phenylthiocarbamyl)acetoacetate (HEPTA) with Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Pd(II) have been prepared and characterized on the basis of elemental analyses, molar conductance, magnetic moment and spectral (UV-Visible, ESR and IR) studies. IR spectra show that HEPTA behaves in a neutral or mononegative bidentate manner. A tetrahedral structure is proposed for the Co(II) complex while a square-planar structure is proposed for the Ni(II), Cu(II) and Pd(II) complexes. The thermal stability and the decomposition steps of [Ni(EPTA)2] and [Cu(EPTA)(OAc)] were investigated with the help of TG thermograms. The Ni(II) and Co(II) complexes show two well defined electrode processes M(I)/M(II) and M(II)/M(III) in dimethylform-amide(DMF), while the Cu(II) complex shows one electrode couple assigned to Cu(II/I).

Molecular modeling and antioxidant activity of newly synthesized 3?hydroxy-2-substituted-thiophene derivatives

A facile synthesis of 3?hydroxy-4-(4-hydroxyphenylazo)thiophenes with various functional groups at position-2 of thiophene ring and their corresponding O-acetylated products is described. The synthetic strategy is based on cyclization of the precursor ethyl 2-(2-(4-hydroxyphenyl)hydrazono)-3-(phenylamino)-3-thioxopropanoate with the appropriate α-chlorinated reagents (namely; chloroacetone, phenacyl chloride, ethyl chloroacetate and chloroacetonitrile). The produced 3?hydroxy-4-(4-hydroxyphenylazo)thiophenes were acetylated upon heating in acetic anhydride to yield the corresponding 3?hydroxy-4-(4-acetoxyphenylazo)thiophenes and/or 3-acetoxy-4-(4-acetoxyphenylazo)thiophenes. The synthesized thiophene derivatives were characterized by IR, 1H NMR and mass spectroscopic analyses. The DFT modeling of the synthesized derivatives offered a reasonable description about why the acetylation reaction was occurred on the phenolic O[sbnd]H group rather than the O[sbnd]H group at position-3 of thiophene ring. While in case of 2-cyano-3?hydroxy-4-(4-hydroxyphenylazo)-5-(phenylamino)-thiophene, both hydroxyl groups were acetylated. The antioxidant activities for the synthesized compounds were assessed through DPPH technique. The 3-hydroxythiophene derivatives 5a-c displayed significant activity with IC50 values (3.01–26.27 μg/mL) using BHA, BHT and ascorbic acid as reference antioxidants. Meanwhile, the results of molecular docking study that applied on the synthesized thiophene derivatives supported the experimental antioxidant assay.