58173-46-9Relevant academic research and scientific papers
Highly stereoselective synthesis of natural-product-like hybrids by an organocatalytic/multicomponent reaction sequence
Echemendía, Radell,De La Torre, Alexander F.,Monteiro, Julia L.,Pila, Michel,Corrêa, Arlene G.,Westermann, Bernhard,Rivera, Daniel G.,Paix?o, Márcio W.
, p. 7621 - 7625 (2015/06/25)
In an endeavor to provide an efficient route to natural product hybrids, described herein is an efficient, highly stereoselective, one-pot process comprising an organocatalytic conjugate addition of 1,3-dicarbonyls to α,β-unsaturated aldehydes followed by
Design, synthesis and biological evaluation of novel L-isoserine tripeptide derivatives as aminopeptidase N inhibitors
Pan, Huili,Yang, Kanghui,Zhang, Jian,Xu, Yingying,Jiang, Yuqi,Yuan, Yumei,Zhang, Xiaopan,Xu, Wenfang
, p. 717 - 726 (2013/07/26)
Aminopeptidase N (APN/CD13) is one of the essential proteins for tumour invasion, angiogenesis and metastasis as it is over-expressed on the surface of different tumour cells. Based on our previous work that L-isoserine dipeptide derivatives were potent APN inhibitors, we designed and synthesized L-isoserine tripeptide derivatives as APN inhibitors. Among these compounds, one compound 16l (IC50=2.51±0.2 M) showed similar inhibitory effect compared with control compound Bestatin (IC50=6.25±0.4 M) and it could be used as novel lead compound for the APN inhibitors development as anticancer agents in the future.
Synthesis and precursor-directed biosynthesis of new hormaomycin analogues
Zlatopolskiy, Boris D.,Radzom, Markus,Zeeck, Axel,De Meijere, Armin
, p. 1525 - 1534 (2007/10/03)
Several new analogues of hormaomycin (1), a peptide lactone with interesting biological activities, were prepared by total synthesis or by precursor-directed biosynthesis. The new analogues 2a-c, 3a-c, O-MOM-1 and epi-O-MOM-1 as well as the model acyl tri
Covalently bonded platinum(II) complexes of α-amino acids and peptides as a potential tool for protein labeling
Guillena, Gabriela,Rodriguez, Gema,Albrecht, Martin,Van Koten, Gerard
, p. 5368 - 5376 (2007/10/03)
Arylplatinum(II) complexes have been covalently bonded to the N and C termini and to the α-carbon of various amino acid derivatives. These organometallic-functionalized amino acid compounds can be converted into the corresponding free amino acids under bo
