58175-89-6

Upstream product

• 302-79-4 all-trans-retinoic-acid 
• 53839-60-4 retinoyl chloride 
• 68-26-8 RETINOL 
• 538-75-0 dicyclohexyl-carbodiimide 

Downstream Products

• 94731-66-5 N-(N-retinoyl)-L-leucyldoxorubicin 14-linoleate 

Relevant academic research and scientific papers

OPHTHALMIC COMPOSITIONS

A composition comprises: a base oil; an additive; and a drug. The additive has segments which are conjugated, e.g. covalently linked, together. A first segment facilitates solubility in the base oil, whereas a second segment facilitates drug solubility an

Carotenoids with two chromophores: Carotenoid retinoates

In this study, carotenoid retinoates are described for the first time. The preparation was achieved by the azolide method. Various sec carotenols reacted with N-retinoylimidazol in the presence of catalytic amounts of sodium hydride. Mono- and diretinoates of (3R,3′R)-zeaxanthin and its (3S,3′S)- enantiomer, (9Z,9′Z; 3R,3′R)-alloxanthin, (3R,3′R)-7,8, 7′,8′-tetrahydro-3,3′-dihydroxy-β,β-carotene-8, 8′-dione and (3R,6R,3′R,6′R)-ε,ε-carotene-3, 3′-diol (lactucaxanthin), as well as monoretinoates of (3R,3′RS,6′R)-3′-methoxy-β,ε-caroten-3-ol, (3R,3′RS,6′R)-3-methoxy-β,ε-caroten-3′-ol, (2R,6′RS)-β,ε-caroten-2-ol, (3R,3′S; meso)-astaxanthin and (2′R)-aleuriaxanthin are reported in this study. Spectroscopic properties (1H-NMR mass spectrometry, visible and circular dichroism spectra) are discussed. Studies on other carotenoid derivatives with two chromophores are referred to here.

Retinol derivatives and process for preparing same

The present invention relates to a new retinyl retinoate, a process for preparing same, a new intermediate which is useful for preparing same, and a cosmetic composition comprising the retinyl retinoate as the active ingredient.

Synthesis of the 3-o-retinoyl-l-ascorbic acid and related compounds: Characterization and reducing activity against DPPH

Novel hybrid vitamin, 3-O-retinoyl-L-ascorbic acid (3a) was conveniently prepared by reaction of sodium L-ascorbate with retinoyl fluoride. The 3-O-acylated structure was confirmed by the comparison of spectral data of its methylated compound with those of 3-O-methyl-2-O-retinoyl-L-ascorbic acid (20) prepared from 5,6-O-isopropylidene-3-O-methyl-L-ascorbic acid. 3-O-Retinoyl-L-ascorbic acid (3a) showed a reducing activity against the stable radical, α,α-diphenyl-β-picrylhydrazyl (DPPH).

SYNTHETIC INVESTIGATIONS IN THE CHEMISTRY OF POLYENE COMPOUNDS LI. SYNTHESIS OF THE ANHYDRIDES OF ISOMERIC RETINOIC ACIDS

A series of anhydrides of isomeric retinoic acids, which are biologically active retinoids, were synthesized.It was shown that three alternative methods can be used for the synthesis of the symmetrical anhydride of all-(E)-retinoic acid.Decomposition of t

Selective uptake of a toxic lipophilic anthracycline derivative by the low-density lipoprotein receptor pathway in cultured fibroblasts

N-(N-Retinoyl)-L-leucyldoxorubicin 14-linoleate (r11-DOX), a new lipophilic derivative of doxorubicin, was synthesized and incorporated into low-density lipoprotein (LDL). The drug-LDL complex contained 100-200 drug molecules/LDL particle. When cultured n