58178-08-8Relevant articles and documents
An Efficient Greener Approach for N-acylation of Amines in Water Using Benzotriazole Chemistry
Ibrahim, Tarek S.,Seliem, Israa A.,Panda, Siva S.,Al-Mahmoudy, Amany M.M.,Abdel-Samii, Zakaria K.M.,Alhakamy, Nabil A.,Asfour, Hani Z.,Elagawany, Mohamed
, (2020/06/17)
A straightforward, mild and cost-efficient synthesis of various arylamides in water was accomplished using versatile benzotriazole chemistry. Acylation of various amines was achieved in water at room temperature as well as under microwave irradiation. The developed protocol unfolds the synthesis of amino acid aryl amides, drug conjugates and benzimidazoles. The environmentally friendly synthesis, short reaction time, simple workup, high yields, mild conditions and free of racemization are the key advantages of this protocol.
Role of benzimidazole (Bid) in the δ-opioid agonist pseudopeptide H-Dmt-Tic-NH-CH2-Bid (UFP-502)
Salvadori, Severo,Fiorini, Stella,Trapella, Claudio,Porreca, Frank,Davis, Peg,Sasaki, Yusuke,Ambo, Akihiro,Marczak, Ewa D.,Lazarus, Lawrence H.,Balboni, Gianfranco
, p. 3032 - 3038 (2008/09/19)
H-Dmt-Tic-NH-CH2-Bid (UFP-502) was the first δ-opioid agonist prepared from the Dmt-Tic pharmacophore. It showed interesting pharmacological properties, such as stimulation of mRNA BDNF expression and antidepression. To evaluate the importance of 1H-benzimidazol-2-yl (Bid) in the induction of δ-agonism, it was substituted by similar heterocycles: The substitution of NH(1) by O or S transforms the reference δ-agonist into δ-antagonists. Phenyl ring of benzimidazole is not important for δ-agonism; in fact 1H-imidazole-2-yl retains δ-agonist activity.
Formation of novel 1-D chains by μ-amido bridging of dinuclear manganese(III)-Schiff base complexes
Bermejo, Manuel R.,Gonzalez-Noya, Ana M.,Abad, Victor,Fernandez, M. Isabel,Maneiro, Marcelino,Pedrido, Rosa,Vazquez, Miguel
, p. 3696 - 3705 (2007/10/03)
Three novel neutral manganese(III) complexes of stoichiometry Mn(R-amsal-3,5-di-tBu)(H2O)n [H3-R-amsal-3,5- di-tBu = 3-aza-4-(2-hydroxyphenyl)-N-(2-hydroxyphenyl)but-3-enamide; (R = H, 4-Me, 5-tBu)] have been synthesised u
A simplified route to the synthesis of new 99mTc-specific tetradentate ligands
Le Gal, Julien,Benoist, Eric,Gressier, Marie,Coulais, Yvon,Dartiguenave, Michèle
, p. 9295 - 9297 (2007/10/03)
The synthesis of two new N2S2 or N2SO tetradentate ligands and the preparation of their technetium-99m complexes are reported. Each ligand leads to a unique 99mTc-complex with an excellent radiochemical yield. T
A direct route to obtain manganese(III) complexes with a new class of asymmetrical Schiff base ligands
Bermejo, Manuel R.,Gonzalez, Ana M.,Fondo, Matilde,Garcia-Deibe, Ana,Maneiro, Marcelino,Sanmartin, Jesus,Hoyos, Olga L.,Watkinson, Michael
, p. 235 - 241 (2007/10/03)
A new class of asymmetrically substituted Schiff base ligands has been synthesised incorporating hard amido donor atoms. The single crystal X-ray structure of one of these ligands, H3-amsal, has been determined [H3-amsal = 3-aza-4-(2
