581807-68-3

Upstream product

• 103323-61-1 1-bromo-2,5-dimethoxy-3,4-dimethylbenzene 
• 39021-83-5 3,6-dimethoxy-o-xylene 
• 86489-95-4 2,5-dimethoxy-3,4-dimethylbenzaldehyde 

Downstream Products

• 581807-69-4 2-hydroxy-3,4-dimethyl-5-(tetrahydro-pyran-2-yloxy)-benzaldehyde 
• 855286-83-8 5-bromo-6-hydroxy-7,8-dimethyl-2-oxo-2H-chromene-3-carboxylic acid 
• 854661-82-8 2-bromo-3,6-dihydroxy-4,5-dimethyl-benzaldehyde 

Relevant academic research and scientific papers

Total synthesis of (R, R, R)-γ-tocopherol through cu-catalyzed asymmetric 1,2-addition

Based on the asymmetric copper-catalyzed 1,2-addition of Grignard reagents to ketones, (R, R, R)-γ-tocopherol has been synthesized in 36% yield over 12 steps (longest linear sequence). The chiral center in the chroman ring was constructed with 73% ee by the 1,2-addition of a phytol-derived Grignard reagent to an a-bromo enone prepared from 2,3-dimethylquinone.

Treatment of mitochondrial diseases

The invention relates the method of treatment or amelioration of mitochondrial disorders such as Alzheimer's disease, Parkinson's disease, Friedreich's ataxia (FRDA), cerebellar ataxias, Leber's hereditary optic neuropathy (LHON), mitochondrial myopathy,