58186-28-0

Upstream product

• 58186-27-9 Idebenone 
• 108-24-7 acetic anhydride 
• 58185-99-2 10-(2,3-Dimethoxy-5-methyl-1,4-benzoquinon-6-yl)decanoic acid 
• 77712-30-2 6-(10-acetoxydecyl)-2,3-dimethoxy-5-methylphenol 
• 14065-32-8 methyl 10-chloro-10-oxodecanoate 
• 818-88-2 sebacic acid mono methyl ester 
• 374622-25-0 1-(2,3,4,5-tetramethoxy-6-methylphenyl)-1,10-decenediol 
• 374622-17-0 methyl 10-(2,3,4,5-tetramethoxy-6-methylphenyl)-10-undecenoate 
• 374622-18-1 10-methylcarbonyloxy-1-(2,3,4,5-tetramethoxy-6-methylphenyl)decylacetate 
• 6946-46-9 9-ethoxycarbonylnonanoic acid chloride 
• 6443-69-2 3,4,5-trimethoxytoluene 
• 58185-85-6 10-(2'-hydroxy-3',4'-dimethoxy-6'-methylphenyl)decanoic acid 
• 58185-79-8 9-(2-hydroxy-3,4-dimethoxy-6-methylbenzoyl)nonanoic acid 
• 55362-80-6 9-bromononan-1-ol 

Downstream Products

• 95233-55-9 6-(10-Acetoxydecyl)-2,3-dimethoxy-5-methylhydroquinone 
• 58186-27-9 Idebenone 
• 95233-73-1 potassium salt of 6-(10-hydroxydecyl)-2,3-dimethoxy-5-methylhydroquinone 4-sulfate 
• 95233-58-2 C₂₁H₃₂O₁₂S₂^(2-)*2Na⁽¹⁺⁾ 
• 95233-57-1 C₂₁H₃₃O₉S^(1-)*Na⁽¹⁺⁾ 
• 95233-56-0 C₂₁H₃₃O₉S^(1-)*Na⁽¹⁺⁾ 
• 95233-60-6 C₂₁H₃₃O₉S^(1-)*K⁽¹⁺⁾ 
• 95233-59-3 C₂₁H₃₃O₉S^(1-)*K⁽¹⁺⁾ 
• 95233-74-2 C₁₉H₃₁O₈S^(1-)*K⁽¹⁺⁾ 
• 96022-21-8 ethyl 2-<10-<3,4-dimethoxy-2,5-di(methoxymethoxy)-6-methylphenyl>decylidene>-3-oxotetracosanoate 
• 96012-42-9 ethyl 2-<10-<3,4-dimethoxy-2,5-di(methoxymethoxy)-6-methylphenyl>decyl>-3-hydroxytetracosanoate 
• 86515-55-1 2-<10-<3,4-dimethoxy-2,5-di(methoxymethoxy)-6-methylphenyl>decyl>-3-hydroxytetracosanoic acid 
• 86515-60-8 10-<3,4-dimethoxy-2,5-di(methoxymethoxy)-6-methylphenyl>decanal 
• 96012-40-7 10-<3,4-dimethoxy-2,5-di(methoxymethoxy)-6-methylphenyl>-1-decanol 

Relevant academic research and scientific papers

Synthetic route discovery and introductory optimization of a novel process to idebenone

An environmentally benign, convenient, high yielding, and cost-effective synthesis leading to idebenone is disclosed. The synthesis includes a bromination process for the preparation of 2-bromo-3,4,5-trimethoxy-1- methylbenzene, a protocol for the Heck cross-coupling reaction using either thermal or microwave heating, olefin reduction by palladium catalyzed hydrogenation, and a green oxidation protocol with hydrogen peroxide as oxidant to achieve the benzoquinone framework. The total synthesis is composed of six steps that provide an overall yield of 20% that corresponds to a step yield of 76%.

Synthesis of idebenone; a synthetic analog of coenzyme Q

Idebenone, a synthetic analog of coenzyme Q, was prepared from the tetramethoxytoluene 2. Two main transformations in this procedure are Friedel-Crafts acylation of 2 to 4 and CAN assisted oxidation of 7 to the quinone 8.

Hydroquinone derivatives and intermediates for production thereof

There are disclosed novel hydroquinone derivatives of the formulas: STR1 The derivatives of the formula (I) have various pharmacological activities such as antioxidation in living bodies and are useful as medicaments, and the derivatives of the formula (II) are intermediates for the production thereof.

Method of producing quinone derivatives

A quinone compound of the formula: STR1 wherein R stands for an alkyl group of 1 to 22 carbon atoms having at its terminal end a hydroxyl group which may be protected, can be obtained with industrial advantage by allowing a compound of the formula: STR2 t

Synthesis, and the adjuvant and tumor-suppressive activities of quinonyl muramyl dipeptides

A description is given of the synthesis and immunological activities of quinonyl muramyl dipeptide lakyl ester derivatives and a new general procedure for the synthesis of quinonyl acids, including mycoloyl-type quinonyl acid, having a long hydrocarbon ch

Aralkyl carboxylic acid compounds

Novel compounds of the formulae STR1 wherein R represents lower alkyl or lower alkoxy, A represents --CH2 --, --CO-- or STR2 n represents an integer of 1 to 8, X represents hydrogen or hydroxyl which may be protected and Y represents hydroxyl which may be protected, and their esters show an excellent action on the lysosomal membranes of cells, and exhibit excellent pharmacological activities such as physiologic host defense control activity, especially immuno-potentiating activity.