582289-84-7

Usage

Uses

Used in Pharmaceutical Industry:
3,4-Bis[(tetrahydro-2H-pyran-2-yl)oxy]benzeneacetic Acid Methyl Ester is used as an intermediate in the synthesis of Dopal (D533885) for its role in the production of pharmaceutical compounds. 3,4-Bis[(tetrahydro-2H-pyran-2-yl)oxy]benzeneacetic Acid Methyl Ester is essential in the development of medications targeting the central nervous system, particularly those related to dopamine and its metabolites.
Used in Chemical Research:
3,4-Bis[(tetrahydro-2H-pyran-2-yl)oxy]benzeneacetic Acid Methyl Ester is also used as a research compound in the field of chemistry. Its unique structure and properties make it a valuable tool for studying the synthesis and properties of various chemical compounds, particularly those related to catecholamines and their metabolites.

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 25379-88-8 2-(3,4-dihydroxyphenyl)acetic acid methyl ester 
• 102-32-9 3,4-dihydroxyphenylacetate 

Downstream Products

• 582289-86-9 2-(3,4-bis(tetrahydropyran-2-yloxy)phenyl)-2-hydroxyacetic acid methyl ester 
• 582289-85-8 3,4-bis(tetrahydropyran-2-yloxy)phenylacetaldehyde 
• 582289-87-0 2-(3,4-bis(tetrahydropyran-2-yloxy)phenyl)-2-(tetrahydropyran-2-yloxy)acetic acid methyl ester 
• 582289-88-1 2-(3,4-bis(tetrahydropyran-2-yloxy)phenyl)-2-(tetrahydropyran-2-yloxy)acetaldehyde 
• 13023-73-9 2-(3,4-dihydroxyphenyl)-2-hydroxyacetaldehyde 
• 5707-55-1 3,4-Dihydroxyphenylacetaldehyde 

Relevant academic research and scientific papers

Structure–Activity Relationship of Anti-malarial Allylpyrocatechol Isolated from Piper betle

Malaria disease remains a serious worldwide health problem. In South-East Asia, one of the malaria infection “hot-spots,” medicinal plants such as Piper betle have traditionally been used for the treatment of malaria, and allylpyrocatechol (1), a constituent of P. betle, has been shown to exhibit anti-malarial activities. In this study, we verified that 1 showed in vivo anti-malarial activity through not only intraperitoneal (i.p.) but also peroral (p.o.) administration. Additionally, some analogs of 1 were synthesized and the structure–activity relationship was analyzed to disclose the crucial sub-structures for the potent activity.

Convenient syntheses of biogenic aldehydes, 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde

The title compounds were prepared from a common precursor, a bis-THP-protected dihydroxyphenylacetic acid methyl ester. Key steps are the introduction of the α-hydroxyl group by Davis oxaziridine reagent and formation of the aldehydes by DIBALH ester reduction.