582289-84-7

Basic information

• Product Name: 3,4-Bis[(tetrahydro-2H-pyran-2-yl)oxy]benzeneacetic Acid Methyl Ester
• Synonyms: 3,4-Bis[(tetrahydro-2H-pyran-2-yl)oxy]benzeneacetic Acid Methyl Ester
• CAS NO: 582289-84-7
• Molecular Formula: C₁₉H₂₆O₆
• Molecular Weight: 350.40614
• Mol File: 582289-84-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 479.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.178±0.06 g/cm3(Predicted)
• Solubility: DCM
• CAS DataBase Reference: 3,4-Bis[(tetrahydro-2H-pyran-2-yl)oxy]benzeneacetic Acid Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Bis[(tetrahydro-2H-pyran-2-yl)oxy]benzeneacetic Acid Methyl Ester(582289-84-7)
• EPA Substance Registry System: 3,4-Bis[(tetrahydro-2H-pyran-2-yl)oxy]benzeneacetic Acid Methyl Ester(582289-84-7)

Safety Data

• Hazardous Substances Data: 582289-84-7(Hazardous Substances Data)

Usage

Uses

3,4-Bis[(tetrahydro-2H-pyran-2-yl)oxy]benzeneacetic Acid Methyl Ester i s an intermediate in the synthesis of Dopal (D533885), the reactive metabolite of dopamine (D533780), an endogenous catecholamine with α and β-adrenergic activity.

Upstream product

• 102-32-9 3,4-dihydroxyphenylacetate 
• 110-87-2 3,4-dihydro-2H-pyran 
• 25379-88-8 2-(3,4-dihydroxyphenyl)acetic acid methyl ester 

Downstream Products

• 13023-73-9 2-(3,4-dihydroxyphenyl)-2-hydroxyacetaldehyde 
• 5707-55-1 3,4-Dihydroxyphenylacetaldehyde 
• 582289-86-9 2-(3,4-bis(tetrahydropyran-2-yloxy)phenyl)-2-hydroxyacetic acid methyl ester 
• 582289-85-8 3,4-bis(tetrahydropyran-2-yloxy)phenylacetaldehyde 
• 582289-87-0 2-(3,4-bis(tetrahydropyran-2-yloxy)phenyl)-2-(tetrahydropyran-2-yloxy)acetic acid methyl ester 
• 582289-88-1 2-(3,4-bis(tetrahydropyran-2-yloxy)phenyl)-2-(tetrahydropyran-2-yloxy)acetaldehyde 

Relevant articles and documents

Structure–Activity Relationship of Anti-malarial Allylpyrocatechol Isolated from Piper betle

Malaria disease remains a serious worldwide health problem. In South-East Asia, one of the malaria infection “hot-spots,” medicinal plants such as Piper betle have traditionally been used for the treatment of malaria, and allylpyrocatechol (1), a constituent of P. betle, has been shown to exhibit anti-malarial activities. In this study, we verified that 1 showed in vivo anti-malarial activity through not only intraperitoneal (i.p.) but also peroral (p.o.) administration. Additionally, some analogs of 1 were synthesized and the structure–activity relationship was analyzed to disclose the crucial sub-structures for the potent activity.