582289-85-8

Basic information

• Product Name: 3,4-Bis[(tetrahydro-2H-pyran-2-yl)oxy]benzeneacetaldehyde
• Synonyms: 3,4-Bis[(tetrahydro-2H-pyran-2-yl)oxy]benzeneacetaldehyde
• CAS NO: 582289-85-8
• Molecular Formula: C₁₈H₂₄O₅
• Molecular Weight: 320.38016
• Mol File: 582289-85-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 479.1±45.0 °C(Predicted)
• Appearance: /
• Density: 1.166±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 3,4-Bis[(tetrahydro-2H-pyran-2-yl)oxy]benzeneacetaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Bis[(tetrahydro-2H-pyran-2-yl)oxy]benzeneacetaldehyde(582289-85-8)
• EPA Substance Registry System: 3,4-Bis[(tetrahydro-2H-pyran-2-yl)oxy]benzeneacetaldehyde(582289-85-8)

Safety Data

• Hazardous Substances Data: 582289-85-8(Hazardous Substances Data)

Usage

Uses

3,4-Bis[(tetrahydro-2H-pyran-2-yl)oxy]benzeneacetaldehyde is an intermediate in the synthesis of Dopal (D533885), the reactive metabolite of dopamine (D533780), an endogenous catecholamine with α and β-adrenergic activity.

Upstream product

• 25379-88-8 2-(3,4-dihydroxyphenyl)acetic acid methyl ester 
• 102-32-9 3,4-dihydroxyphenylacetate 
• 582289-84-7 3,4-bis(tetrahydropyran-2-yloxy)phenylacetic acid methyl ester 

Downstream Products

• 5707-55-1 3,4-Dihydroxyphenylacetaldehyde 

Relevant articles and documents

Structure–Activity Relationship of Anti-malarial Allylpyrocatechol Isolated from Piper betle

Malaria disease remains a serious worldwide health problem. In South-East Asia, one of the malaria infection “hot-spots,” medicinal plants such as Piper betle have traditionally been used for the treatment of malaria, and allylpyrocatechol (1), a constituent of P. betle, has been shown to exhibit anti-malarial activities. In this study, we verified that 1 showed in vivo anti-malarial activity through not only intraperitoneal (i.p.) but also peroral (p.o.) administration. Additionally, some analogs of 1 were synthesized and the structure–activity relationship was analyzed to disclose the crucial sub-structures for the potent activity.