582322-04-1Relevant articles and documents
Chondroitin sulfate oligosaccharides and preparation method and applications thereof
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Paragraph 0094; 0105-0107, (2019/08/06)
The invention discloses a series of chondroitin sulfate oligosaccharides as shown in a formula and a preparation method and biological activity thereof, and intermediates and a synthesis method of theintermediates. The key points of the invention are as f
An investigation of construction of chondroitin sulfate E (CS-E) repeating unit
Yang, Shuang,Wang, A-peng,Zhang, Guangyan,Di, Xiangjie,Zhao, Zhehui,Lei, Pingsheng
, p. 5659 - 5670 (2016/08/23)
A series of the derivatives of chondroitin sulfate E (CS-E) disaccharide repeating unit were prepared by postglycosylation–oxidation strategy. The strategy showed excellent performance in glycosylation both on the reactivity and stereoselectivity. Different protecting methodologies were used for the manipulation of disaccharide building blocks. Substitutes at C-4 of glucosyl donors mildly influenced the glycosylation. The current synthesis afforded a feasible approach for the preparation of CS-E repeating unit.
FeCl3 mediated arylidenation of carbohydrates
Basu, Nabamita,Maity, Sajal K.,Roy, Soumik,Singha, Shuvendu,Ghosh, Rina
experimental part, p. 534 - 539 (2011/04/27)
Glycosides and thioglycosides based on monosaccharides in reaction with benzaldehyde dimethylacetal or p-methoxybenzaldehyde dimethyl acetal undergo FeCl3-catalyzed (20 mol %) regioselective 4,6-O-arylidenation producing the corresponding acetals in high yields. FeCl3 also mediates acetalation of glycosides and thioglycosides of cellobiose, maltose, and lactose affording the corresponding 4′,6′-O-benzylidene acetals, which were isolated after their acetylation in situ with acetic anhydride and pyridine. The combined yields (two steps) of these final products are also high (61-84%). The procedure is applicable to a wide variety of functional groups including -OBn.
SMALL MOLECULE STIMULATORS OF NEURONAL GROWTH
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Page/Page column 22; 44, (2008/06/13)
Provided herein are small molecule stimulators of neuronal growth, their preparation, and their use for treatment of neurological disorders. In one embodiment, provided herein are methods of treatment, prevention, or amelioration of a variety of medical c
Stripping off water at ambient temperature: Direct atom-efficient acetal formation between aldehydes and diols catalyzed by water-tolerant and recoverable vanadyl triflate
Chen, Chien-Tien,Weng, Shiue-Shien,Kao, Jun-Qi,Lin, Chun-Cheng,Jan, Mi-Dan
, p. 3343 - 3346 (2007/10/03)
(Chemical Equation Presented) Aromatic aldehydes can be readily protected as acetals with 1,2- and 1,3-diols by using vanadyl triflate as a catalyst in CH3CN at ambient temperature. Carbohydrate-based 1,2- and 1,3-diols can similarly be protected in good to excellent yields. The catalyst can be readily recovered from the aqueous layer. In combination with vanadyl triflate-catalyzed sequential regioselective, reductive acetal opening and chemoselective acylations, the title method allows for differential functionalization of all four hydroxyl units in a given glucopyranoside.
A chondroitin sulfate small molecule that stimulates neuronal growth
Tully, Sarah E.,Mabon, Ross,Gama, Cristal I.,Tsai, Sherry M.,Liu, Xuewei,Hsieh-Wilson, Linda C.
, p. 7736 - 7737 (2007/10/03)
Chondroitin sulfate glycosaminoglycans are sulfated polysaccharides involved in cell division, neuronal development, and spinal cord injury. Here, we report the synthesis and identification of a chondroitin sulfate tetrasaccharide that stimulates the grow
Synthesis of aminocyclohexitol via carbon-carbon bond-forming radical cyclization of oxime ether.
Miyabe, Hideto,Nishiki, Akiyoshi,Naito, Takeaki
, p. 100 - 103 (2007/10/03)
The stannyl radical mediated-cyclization of oxime ether, derived from D-glucose, gave the aminocyclohexitol derivative. Stereoselective C-C bond forming cyclization proceeded via favorable conformers minimizing A(1,3)-strain between the oxime ether group and alpha-substituents.