58237-94-8

Usage

Uses

Used in Pharmaceutical Industry:
N-BOC-2-(INDOLE-3-YL)-DL-GLYCINE is used as a building block for the synthesis of various pharmaceutical compounds. Its unique structure, including the indole group, can provide specific properties and functions to the synthesized compounds, making it a valuable component in the development of new drugs.
Used in Peptide Synthesis:
N-BOC-2-(INDOLE-3-YL)-DL-GLYCINE is used as a protected amino acid in peptide synthesis. The N-BOC protecting group allows for the selective incorporation of the compound into peptides without unwanted side reactions. This feature is particularly useful in the synthesis of complex peptide sequences and the development of novel peptide-based therapeutics.
Used in Research and Development:
N-BOC-2-(INDOLE-3-YL)-DL-GLYCINE is used as a research tool in the study of amino acid chemistry, peptide synthesis, and the development of new synthetic methods. Its unique structure and properties make it an interesting compound for exploring new reactions and applications in the field of organic chemistry and biochemistry.

InChI:InChI=1/C15H18N2O4/c1-15(2,3)21-14(20)17-12(13(18)19)10-8-16-11-7-5-4-6-9(10)11/h4-8,12,16H,1-3H3,(H,17,20)(H,18,19)

Upstream product

• 110317-49-2 N-(tert-Butyloxycarbonyl)-2-(3-indolyl)glycin-methylester 
• 18372-22-0 2-(3-indolyl)oxoacetic acid methyl ester 
• 110317-48-1 methyl 2-amino-2-(1H-indol-3-yl)acetate 
• 113975-75-0 methyl indol-3-ylglyoxylate oxime 
• 102831-44-7 diethyl tert-butoxycarbonylaminomalonate 
• 120-72-9 indole 

Downstream Products

• 6747-15-5 α-amino-(+/)-3-indoleacetic acid 

Relevant academic research and scientific papers

Novel synthesis method of indole glycinate

The invention relates to a novel synthesis method of indole glycinate. A substituted indole glycinate derivative 3 is obtained after indole 1, acylamino malonate 2 and an oxidant as raw materials are heated to 60-100 DEG C in an organic solvent under the protection of nitrogen and are subjected to a cross dehydrogenation coupling reaction, an obtained product is treated and subjected to hydrolysis and decarboxylation under the alkaline condition, a product 4 is obtained and subjected to hydrolysis deprotection under the alkaline condition, and a final indole glycinate product 5 is obtained through acidification. Indole 1, acylamino malonate 2 and the oxidant are taken as the raw materials, the raw materials are cheap and easy to obtain, a substrate range is wide, the compatibility of a functional group is good, and final indole glycinate can be obtained in a higher yield from various substituted indole and acylamino malonate. The method has multiple advantages that the synthesis route is short, the reaction raw materials are low in toxicity, separation and purification are convenient and the like, and has great practical application value in synthesis of the compounds.

Syntheses of bis(3'-indolyl)-2(1H)-pyrazinones

The syntheses of 3,6-bis(3'-indolyl)-2(1H)-pyrazinone and 3,5- bis(3'indolyl)-2(1H)-pyrazinone were described. Syntheses of 3,6-bis(3'- indolyl)-2(1H)-pyrazinone proceeded through the condensation of N-Boc- indolylglycine with indol-3-yl-N-methyl-O-methox

Process for preparing substituted glycines

A new process is disclosed for the preparation of N-acyl-α-aromatic and N-acyl-α-heteroaromatic glycines by reaction of an α-ester or ether of an N-acylglycine ester or acid with an aromatic or heteroaromatic compound. Also disclosed are new intermediates for preparing N-acyl-α-aromatic and N-acyl-α-heteroaromatic glycines.