5824-58-8

Basic information

• Product Name: 3-(Phosphono)pyruvic acid
• Synonyms: 2-Oxo-3-phosphonopropanoic acid;3-(Dihydroxyphosphinyl)pyruvic acid;3-(Phosphono)pyruvic acid;3-Phosphonopyruvic acid;Phosphonopyruvic acid
• CAS NO: 5824-58-8
• Molecular Formula: C₃H₅O₆P
• Molecular Weight: 168.041961
• Product Categories: Aliphatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 5824-58-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(Phosphono)pyruvic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Phosphono)pyruvic acid(5824-58-8)
• EPA Substance Registry System: 3-(Phosphono)pyruvic acid(5824-58-8)

Safety Data

• Hazardous Substances Data: 5824-58-8(Hazardous Substances Data)

Usage

Uses

A novel carbon-phosphorus bond cleavage enzyme from Variovorax sp. Pal2.

Upstream product

• 5652-28-8 DL-2-amino-3-phosphonopropionic acid 
• 138-08-9 phosphoenolpyruvic acid 

Downstream Products

• 113-24-6 sodium pyruvate 
• 16051-76-6 phosphonoacetalhdehyde 
• 138-08-9 phosphoenolpyruvic acid 

Relevant articles and documents

Studies on the biosynthesis of bialaphos. Biochemical mechanism of C-P bond formation: Discovery of phosphonopyruvate decarboxylase which catalyzes the formation of phosphonoacetaldehyde from phosphonopyruvate

The biosynthetic step following the phosphoenolpyruvate (PEP) phosphomutase reaction which forms a C-P bond of bialaphos was proven by the identification of phosphonopyruvate (PnPy) and phosphonoacetaldehyde (PnAA) as intermediates in the culture broth of Streptomyces hygroscopicus, a producing organism of bialaphos, and by detection of enzymatic decarboxylation of PnPy to PnAA. Purified PnPy decarboxylase turned out to require thiamine diphosphate and Mg2+ as cofactors. PnPy decarboxylase drives the unfavorable forward reaction to form PnPy catalyzed by PEP phosphomutase and is suggested to be essential to C-P compound biosynthesis.