58243-89-3Relevant academic research and scientific papers
An efficient synthesis of (R)-2-Butyl-3-hydroxypropionic acid
Bin, Hu,Prashad, Mahavir,Har, Denis,Prasad, Kapa,Repic, Oljan,Blacklock, Thomas J.
, p. 90 - 93 (2007)
An efficient synthesis of (R)-2-butyl-3-hydroxypropionic acid (1) via a classical resolution of (±)-2-butyl-3-hydroxypropionic acid (7) with (R)-α-methylbenzylamine is described. (±)-2-Butyl-3- hydroxypropionic acid (7) was readily available from diethyl butylmalonate (2) in two steps. Results on the enantioselective enzymatic hydrolysis of 2 with pig liver esterase and α-chymotrypsin towards 1 are also described.
Ligand-Enabled Monoselective β-C(sp3)-H Acyloxylation of Free Carboxylic Acids Using a Practical Oxidant
Fan, Zhoulong,Herron, Alastair N.,Yu, Jin-Quan,Zhuang, Zhe
, p. 6769 - 6776 (2020/04/30)
The development of C-H activation reactions that use inexpensive and practical oxidants remains a significant challenge. Until our recent disclosure of the β-lactonization of free aliphatic acids, the use of peroxides in C-H activation reactions directed by weakly coordinating native functional groups was unreported. Herein, we report C(sp3)-H β-acetoxylation and γ-, δ-, and ?-lactonization reactions of free carboxylic acids enabled by a novel cyclopentane-based mono-N-protected β-amino acid ligand. Notably, tert-butyl hydrogen peroxide is used as the sole oxidant for these reactions. This reaction has several key advantages over other C-H activation protocols: (1) exclusive monoselectivity was observed in the presence of two α-methyl groups; (2) aliphatic carboxylic acids containing α-hydrogens are compatible with this protocol; (3) lactonization of free acids, affording γ-, δ-, or ?-lactones, has been achieved for the first time.
Catalytic hydrogenation of cyclic carbonates: A practical approach from CO2 and epoxides to methanol and diols
Han, Zhaobin,Rong, Liangce,Wu, Jiang,Zhang, Lei,Wang, Zheng,Ding, Kuiling
supporting information, p. 13041 - 13045 (2013/03/13)
As an economical, safe and renewable carbon resource, CO2 turns out to be an attractive C1 building block for making organic chemicals, materials, and carbohydrates.[1] From the viewpoint of synthetic chemistry,[2] the utilization of CO2 as a feedstock for the production of industrial products may be an option for the recycling of carbon.[3] On the other hand, the transformation of chemically stable CO2 represents a grand challenge in exploring new concepts and opportunities for the academic and industrial development of catalytic processes.[4] The catalytic hydrogenation of CO2 to produce liquid fuels such as formic acid (HCO 2H)[5] or methanol[6] is a promising solution to emerging global energy problems. Methanol, in particular, is not only one of the most versatile and popular chemical commodities in the world, with an estimated global demand of around 48 million metric tons in 2010, but is also considered as the key to weaning the world off oil in the future.[6e, f] Although the production of methanol has already been industrialized by the hydrogenation of CO with a copper/zinc-based heterogeneous catalyst at high temperatures (250-300°C) and high pressures (50-100 atm),[6e, 7] the development of a practical catalytic system for the hydrogenation of CO2 into methanol still remains a challenge, as high activation energy barriers have to be overcome for the cleavage of the C=O bonds of CO2, albeit with favorable thermodynamics.[8] Heterogeneous catalysis for the hydrogenation of CO 2 into CH3OH has been extensively investigated, and Cu/Zn-based multi-component catalyst was found to be highly selective with a long life, but under relatively harsh reaction conditions (250 °C, 50 atm).[3b, 6d] Therefore, the production of methanol from CO2 by direct hydrogenation under mild conditions is still a great challenge for both academia and industry.
Regioselective hydroformylation of allylic alcohols
Lightburn, Thomas E.,De Paolis, Omar A.,Cheng, Ka H.,Tan, Kian L.
supporting information; experimental part, p. 2686 - 2689 (2011/06/28)
A highly regioselective hydroformylation of allylic alcohols is reported toward the synthesis of β-hydroxy-acid and aldehyde products. The selectivity is achieved through the use of a ligand that reversibly binds to alcohols in situ, allowing for a directed hydroformylation to occur. The application to trisubstituted olefins was also demonstrated, which yields a single diastereomer product consistent with a stereospecific addition of CO and hydrogen.
Synthesis and in vitro antibacterial activity of oxazolidine LBM-415 analogs as peptide deformylase inhibitors
Yu, Linliang,Zhou, Weicheng,Wang, Zhenyu
scheme or table, p. 1541 - 1544 (2011/04/16)
The drug resistant bacteria pose a severe threat to human health. The increasing resistance of those pathogens to traditional antibacterial therapy renders the identification of new antibacterial agents with novel antibacterial mechanisms an urgent need.
Chemical process for the preparation of intermediates to obtain n-formyl hydroxy-lamine compounds
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Page/Page column 12, (2008/06/13)
Improved processes for preparing intermediates useful for preparing antibacterial N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl}-(carbonylamino-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, which have one or more of the following feat
