234768-83-3Relevant articles and documents
Peptide deformylase inhibitors
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, (2014/12/09)
The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.
Synthesis and in vitro antibacterial activity of oxazolidine LBM-415 analogs as peptide deformylase inhibitors
Yu, Linliang,Zhou, Weicheng,Wang, Zhenyu
, p. 1541 - 1544 (2011/04/16)
The drug resistant bacteria pose a severe threat to human health. The increasing resistance of those pathogens to traditional antibacterial therapy renders the identification of new antibacterial agents with novel antibacterial mechanisms an urgent need.
A practical enantioselective synthesis of a novel peptide deformylase inhibitor
Slade, Joel,Parker, David,Girgis, Michael,Mueller, Martin,Vivelo, James,Liu, Hui,Bajwa, Joginder,Chen, Guang-Pei,Carosi, Joseph,Lee, Paul,Chaudhary, Apurva,Wambser, Dana,Prasad, Kapa,Bracken, Kathryn,Dean, Karl,Boehnke, Helmut,Repic, Oljan,Blacklock, Thomas J.
, p. 78 - 93 (2012/12/21)
A practical synthesis of the peptide deformylase inhibitor LBM415,(2S)-N-(5-fluoro-1-oxido-2-pyridinyl)-1-[(2R)-2-[(formylhydroxyamino) methyl]-1-oxohexyl]-2-pyrrolidinecarboxamide, magnesium salt 11, is described. The key chiral intermediate, (2S)-N-(5-f