58249-89-1

Basic information

• Product Name: 2-methyl-N-(4-methylphenyl)benzamide
• Synonyms: benzamide, 2-methyl-N-(4-methylphenyl)-
• CAS NO: 58249-89-1
• Molecular Formula: C₁₅H₁₅NO
• Molecular Weight: 225.2857
• Mol File: 58249-89-1.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 294.1°C at 760 mmHg
• Flash Point: 175.3°C
• Density: 1.121g/cm³
• Vapor Pressure: 0.00166mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: 2-methyl-N-(4-methylphenyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-N-(4-methylphenyl)benzamide(58249-89-1)
• EPA Substance Registry System: 2-methyl-N-(4-methylphenyl)benzamide(58249-89-1)

Safety Data

• Hazardous Substances Data: 58249-89-1(Hazardous Substances Data)

Usage

General Description

2-Methyl-N-(4-methylphenyl)benzamide is a chemical compound with the molecular formula C15H15NO. It is a crystalline solid at room temperature and is insoluble in water but soluble in organic solvents. The compound is an amide derivative of benzene, with a methyl group and a 4-methylphenyl group attached to the nitrogen and carbon atoms, respectively. It is commonly used in organic synthesis and pharmaceutical research as a building block for creating more complex organic compounds. The compound may also have potential applications in the fields of medicine and material science.

Upstream product

• 106-38-7 para-bromotoluene 
• 527-85-5 o-Methylbenzamid 
• 624-31-7 4-tolyl iodide 
• 22978-37-6 N,2-dimethyl-N-phenylbenzamide 
• 106-49-0 p-toluidine 
• 99-99-0 1-methyl-4-nitrobenzene 
• 16419-60-6 2-Methylphenylboronic acid 
• 13939-06-5 molybdenum hexacarbonyl 
• 13061-96-6 dihydroxy-methyl-borane 
• 19562-37-9 3-(4-methylphenyl)benzo-1,2,3-triazin-4(3H)-one 
• 611-15-4 1-methyl-2-vinyl-benzene 
• 7175-47-5 4-methylphenyl isocyanide 
• 118-90-1 ortho-methylbenzoic acid 
• 104-84-7 para-methylbenzylamine 

Downstream Products

• 4778-84-1 N-(4-methylphenyl)isoindolinone 
• 14959-71-8 3-(4-methoxyphenyl)-2-(p-tolyl)isoquinolin-1(2H)-one 

Relevant articles and documents

Palladium-Catalyzed Annulation of Arylbenzamides with Diaryliodonium Salts

By using diaryliodonium salts, a cylization has been accomplished in the synthesis of N-aryl phenanthridinone derivatives via a cascade of ortho-arylation and Csp2-N bond formation in the presence of palladium catalyst. The reaction exhibits a broad compatibility of readily available N-arylnaphthamides. (Figure presented.).

Palladium-Catalyzed Amide Synthesis via Aminocarbonylation of Arylboronic Acids with Nitroarenes

A palladium-catalyzed aminocarbonylation of aryl boronic acids with nitroarenes for the synthesis of amides has been developed. A wide range of substrates were well-tolerated and gave the corresponding amides in moderate to good yields. No external oxidant or reductant was needed in this procedure. This procedure provides a redox-economical process for the synthesis of amides.

Nickel-Catalyzed Denitrogenative ortho-Arylation of Benzotriazinones with Organic Boronic Acids: an Efficient Route to Losartan and Irbesartan Drug Molecules

Denitrogenative ortho-arylation, vinylation and methylation of 1,2,3-benzotriazin-4-(3H)-ones with organic boronic acids catalyzed by nickel complexes to give a wide range of o-substituted benzamides were demonstrated. Further, the catalytic reaction is successfully applied to the synthesis of the popular hypertensive drugs losartan and irbesartan in high yields. (Figure presented.).