58259-50-0

Upstream product

• 956-82-1 3-methylcyclopentadecanone 
• 31843-96-6 3-methyl-7,8,15,16,23,24-hexaoxatrispiro[5.2.5⁹.2.5¹⁷.2⁶]tetracosane 
• 86162-11-0 1-methyl-cyclopentadecene 
• 141-78-6 ethyl acetate 
• 7647-01-0 hydrogenchloride 

Relevant academic research and scientific papers

Flow Chemistry under Extreme Conditions: Synthesis of Macrocycles with Musklike Olfactoric Properties

Starting from small cyclic ketones, continuous flow synthesis is used to produce medium-sized rings and macrocycles that are relevant for the fragrance industry. Triperoxides are important intermediates in this process and are pyrolyzed at temperatures above 250 °C. The synthesis is carried out in two continuously operated flow reactors connected by a membrane-operated separator. The practicality of flow chemistry is impressively demonstrated in this work by the use of hazardous reagent mixtures (30% H2O2, 65% HNO3) and the pyrolysis of no less problematic peroxides. All new macrocycles were tested for their olfactory properties in relation to musk.