583041-67-2Relevant academic research and scientific papers
Synthesis of poly (3,4,5-trihydroxybenzoate ester) dendrimers and their chemiluminescence
Nakazono, Manabu,Ma, Li,Zaitsu, Kiyoshi
, p. 8185 - 8189 (2002)
Gallic acid (GA) and gallic acid methyl ester (GM), polyphenol chemiluminescence (CL) compounds, produces light in the presence of alkali and hydrogen peroxide. We synthesized first-generation polyphenol dendrimers with GA units in the periphery and measured their CL for developing a polyphenol compound which has a strong CL intensity. The CL intensities of the poly (3,4,5-trihydroxybenzoate ester) dendrimers 4 and 8 in MeOH are approximately 400- and 600-fold stronger than that of GA, respectively.
Promotion of mitochondrial biogenesis by synthetic 1,2- or 1,3-digallates through activation of an energy sensing network
Chong, Youhoon,Kim, Mi Kyoung,Lee, Taegum
, (2022/01/08)
Based on the observations suggesting that a digallate functionality might serve as a novel scaffold for inducers of mitochondrial biogenesis, we prepared a series of digallates and evaluated their activity in an in vitro model widely used in PD research (
Mimic catechins to develop selective MMP-2 inhibitors
Di Pizio, Antonella,Agamennone, Mariangela,Laghezza, Antonio,Loiodice, Fulvio,Tortorella, Paolo
, p. 1293 - 1300 (2018/06/14)
Abstract: Matrix metalloproteinase 2 (MMP-2) is a well-known anticancer target belonging to the MMP family. Because of the bilateral role of MMPs in cancer, developing highly selective MMP-2 inhibitors is a current challenge. In this paper, we investigated the binding modes of green tea polyphenols epigallocatechin gallate and epicatechin into the active site of the MMP-2 enzyme. The structure-based analysis allowed the optimization of these hits and hence led to a better lead candidate. Moreover, using a pharmacophore model, we screened FooDB compounds and selected food components as potential MMP-2 inhibitors. The search for food-derived compounds that target this enzyme may represent a strategy to identify new lead molecules with improved safety profiles and provide indications about possible functional foods. Graphical abstract: [Figure not available: see fulltext.].
New synthetic inhibitors of fatty acid synthase with anticancer activity
Turrado, Carlos,Puig, Teresa,García-Cárceles, Javier,Artola, Marta,Benhamú, Bellinda,Ortega-Gutiérrez, Silvia,Relat, Joana,Oliveras, Gloria,Blancafort, Adriana,Haro, Diego,Marrero, Pedro F.,Colomer, Ramón,López-Rodríguez, María L.
experimental part, p. 5013 - 5023 (2012/07/30)
Fatty acid synthase (FASN) is a lipogenic enzyme that is highly expressed in different human cancers. Here we report the development of a new series of polyphenolic compounds 5-30 that have been evaluated for their cytotoxic capacity in SK-Br3 cells, a hu
Novel inhibitors of basal glucose transport as potential anticancer agents
Zhang, Weihe,Liu, Yi,Chen, Xiaozhuo,Bergmeier, Stephen C.
scheme or table, p. 2191 - 2194 (2010/06/15)
Cancer cells commonly show increased levels of glucose uptake and dependence. A potential strategy for the treatment of cancer may be the inhibition of basal glucose transport. We report here the synthesis of a small library of polyphenolic esters that inhibit basal glucose transport in H1299 lung and other cancer cells. These basal glucose transport inhibitors also inhibit cancer cell growth in H1299 cells, and these two activities appear to be correlated.
