583047-64-7Relevant academic research and scientific papers
Design, efficient synthesis, and anti-HIV activity of 4′-C-cyano- and 4′-C-ethynyl-2′-deoxy purine nucleosides
Kohgo, Satoru,Yamada, Kohei,Kitano, Kenji,Iwai, Yuko,Sakata, Shinji,Ashida, Noriyuki,Hayakawa, Hiroyuki,Nameki, Daisuke,Kodama, Eiichi,Matsuoka, Masao,Mitsuya, Hiroaki,Ohrui, Hiroshi
, p. 671 - 690 (2007/10/03)
Some 4′-C-ethynyl-2′-deoxy purine nucleosides showed the most potent anti-HIV activity among the series of 4′-C-substituted 2′-deoxynucleosides whose 4′-C-substituents were methyl, ethyl, ethynyl and so on. Our hypothesis is that the smaller the substitue
